86963-40-8

Basic information

• Product Name: (R)-alpha-Methylbenzenemethanesulfonic acid
• Synonyms: (R)-alpha-Methylbenzenemethanesulfonic acid
• CAS NO: 86963-40-8
• Molecular Formula: C₈H₁₀O₃S
• Molecular Weight: 186.2282
• Mol File: 86963-40-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.315±0.06 g/cm3(Predicted)
• PKA: 1.52±0.50(Predicted)
• CAS DataBase Reference: (R)-alpha-Methylbenzenemethanesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-alpha-Methylbenzenemethanesulfonic acid(86963-40-8)
• EPA Substance Registry System: (R)-alpha-Methylbenzenemethanesulfonic acid(86963-40-8)

Safety Data

• Hazardous Substances Data: 86963-40-8(Hazardous Substances Data)

Usage

General Description

(R)-alpha-Methylbenzenemethanesulfonic acid is a chemical compound with the molecular formula C8H10O3S. It is commonly used as a chiral resolving agent and as a catalyst in organic synthesis. (R)-alpha-Methylbenzenemethanesulfonic acid is a white to off-white powder that is soluble in water and ethanol. It is often utilized in the production of pharmaceuticals, agrochemicals, and fine chemicals due to its ability to facilitate asymmetric reactions. (R)-alpha-Methylbenzenemethanesulfonic acid is also known by the trade names Camphorsulfonic acid, and is available from various chemical suppliers for use in laboratory and industrial applications.

Upstream product

• 33877-11-1 1-Phenylethanethiol 
• 1939-99-7 benzenesulfonyl chloride 
• 5877-96-3 methyl α-phenylmethanesulfonate 
• 29850-82-6 (+/-)-(S)-(1-phenyl-ethyl)-isothiourea; hydrobromide 
• 98-85-1 1-Phenylethanol 
• 412021-12-6 Phenyl-methanesulfonic acid (3aR,5R,6R,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 424839-30-5 (R)-1-Phenyl-ethanesulfonic acid (3aR,5R,6R,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 33877-16-6 (R)-(+)-1-phenylethyl sulphide 

Relevant articles and documents

Rh/Wudaphos-Catalyzed Asymmetric Hydrogenation of Sodium α-Arylethenylsulfonates: A Method to Access Chiral α-Arylethylsulfonic Acids

A highly enantioselective hydrogenation of various sodium α-arylethenylsulfonates catalyzed by Rh/chiral ferrocenyl bisphosphorus ligand (Wudaphos) was successfully developed to construct a series of chiral α-arylethylsulfonic acids in the presence of CF3SO3H with full conversion and good to excellent enantioselectivity (>99% conversion, up to 96% ee) under mild reaction conditions for the first time. Moreover, the control experiment results showed that the non-covalent ion pair interaction between the α-arylethenylsulfonic acid and the Wudaphos ligand plays an important role in this asymmetric hydrogenation system.

Dutch Resolution: Separation of enantiomers with families of resolving agents. A status report

Dutch Resolution is the term given to the use of mixtures (families) of resolving agents in classical resolutions. In this status report an overview is given of the latest results and new (possible) families of resolving agents are introduced. The concept of families is discussed as well as the factors that come into play on use of families. Practical aspects of Dutch Resolution in particular and resolutions in general are discussed.