869998-49-2

Basic information

• Product Name: SPD-304
• Synonyms: SPD-304;CAY10500;6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one
• CAS NO: 869998-49-2
• Molecular Formula: C32H32F3N3O2
• Molecular Weight: 547.6105896
• Mol File: 869998-49-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: SPD-304(CAS DataBase Reference)
• NIST Chemistry Reference: SPD-304(869998-49-2)
• EPA Substance Registry System: SPD-304(869998-49-2)

Safety Data

• Hazardous Substances Data: 869998-49-2(Hazardous Substances Data)

Usage

Uses

SPD304 has been used in the inhibition of tumor necrosis factor receptor 1 (TNFR1) in dorsal root ganglion neurons and tumor necrosis factor alpha in colonic epithelial cell lines.

Biochem/physiol Actions

SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM.