87-05-8

Basic information

• Product Name: 7-Ethoxy-4-methyl-2H-chromen-2-one
• Synonyms: ETHYL 4-METHYLUMBELLIFERYL ETHER;TIMTEC-BB SBB010011;7-ETHOXY-4-METHYLCOUMARIN, FOR FLUORESCE NCE;Maraniol;7-Ethoxy-4-methylcoumarin 98%;METHYL-7-ETHOXYCOUMARIN, 4-(SG);7-ETHOXY-4-METHYLCOUMARIN WITH GC;4-Methyl-7-ethoxy-2H-1-benzopyran-2-one
• CAS NO: 87-05-8
• Molecular Formula: C₁₂H₁₂O₃
• Molecular Weight: 204.22
• EINECS: 201-721-5
• Product Categories: Coumarins;API intermediates
• Mol File: 87-05-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 114-116 °C(lit.)
• Boiling Point: 351.4 °C at 760 mmHg
• Flash Point: 146.2 °C
• Appearance: /
• Density: 1.163 g/cm³
• Vapor Pressure: 4.12E-05mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMF: soluble
• BRN: 169998
• CAS DataBase Reference: 7-Ethoxy-4-methyl-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Ethoxy-4-methyl-2H-chromen-2-one(87-05-8)
• EPA Substance Registry System: 7-Ethoxy-4-methyl-2H-chromen-2-one(87-05-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• F: 8
• TSCA: Yes
• Hazardous Substances Data: 87-05-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid; walnut odor. Slightly soluble in alcohol.

Uses

Different sources of media describe the Uses of 87-05-8 differently. You can refer to the following data:
1. 7-Ethoxy-4-methylcoumarin was an analyte in a study of the structural characterization and retention time simulation of allergenic fragrances.
2. 7-Ethoxy-4-methylcoumarin may be used in the assay of 4-chlormethyl-7-ethoxycoumarin O-deethylase activity.

General Description

7-Ethoxy-4-methylcoumarin (EtOMC), also known as ethyl 4-methylumbelliferyl ether, is a coumarin derivative. Its standard molar energy of combustion is ?5888.0 ± 3.2kJ·mol?1 and standard molar enthalpy of formation in the crystalline phase is ?545.4 ± 3.6kJ·mol?1.EtOMC can be prepared by reacting methyl acetoacetate with 3-ethoxyphenol in the presence of boron trifluoride dihydrate.The fluorescence quenching of EtOMC is more effective in the presence 4-hydroxy-TEMPO (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl).

InChI:InChI=1/C12H12O3/c1-3-14-9-4-5-10-8(2)6-12(13)15-11(10)7-9/h4-7H,3H2,1-2H3

Upstream product

• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 621-34-1 O-ethyl resorcinol 
• 141-97-9 ethyl acetoacetate 
• 299-45-6 potasan 
• 74-96-4 ethyl bromide 
• 150-19-6 O-methylresorcine 
• 64-67-5 diethyl sulfate 
• 108-46-3 recorcinol 
• 75-03-6 ethyl iodide 
• 4525-25-1 Methyl acetoacetate 
• 31005-02-4 7-ethoxycoumarin 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 24535-08-8 3-(4-Ethoxy-2-hydroxy-phenyl)-buttersaeurehydrazid 
• 97184-69-5 7-Ethoxy-4-methyl-3-(2-phenyl-indol-1-ylmethyl)-chromen-2-one 
• 97184-64-0 3-[(Diphenylamino)-methyl]-7-ethoxy-4-methyl-chromen-2-one 
• 97184-65-1 7-Ethoxy-3-[(ethyl-phenyl-amino)-methyl]-4-methyl-chromen-2-one 
• 97184-62-8 7-Ethoxy-4-methyl-3-[(methyl-phenyl-amino)-methyl]-chromen-2-one 

Relevant articles and documents

Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations

Using a combined structural and biochemical approach, the functional importance of a recently described peripheral pocket bounded by the E-, F-, G-, and I-helices in CYP2B4 and 2B6 was probed. Three series of 4-substituted-7-alkoxycoumarin derivatives with -H, -CH3, or -CF3 at the 4 position of the coumarin core were used initially to monitor functional differences between CYP2B4 and 2B6. 7-Ethoxy-4-(trifluoromethyl)coumarin (7-EFC) displayed the highest catalytic efficiency among these substrates. Mutants were made to alter side-chain polarity (V/E194Q) or bulk (F/Y244W) to alter access to the peripheral pocket. Modest increases in catalytic efficiency of 7-EFC O-deethylation by the mutants were magnified considerably by chlorination or bromination of the substrate ethoxy chain. A structure of CYP2B6 Y244W in complex with (+)-α-pinene was solved at 2.2 ? and showed no CYMAL-5 in the peripheral pocket. A ligand free structure of CYP2B4 F244W was solved at 3.0 ? with CYMAL-5 in the peripheral pocket. In both instances, comparison of the respective wild-type and mutant CYP2B enzymes revealed that CYMAL-5 occupancy of the peripheral pocket had little effect on the topology of active site residue side-chains, despite the fact that the peripheral pocket and active site are located on opposite sides of the I-helix. Analysis of available CYP2B structures suggest that the effect of the amino acid substitutions within the peripheral pocket derive from altered interactions between the F and G helices.

Synthesis, characterisation and photophysical studies of oxadiazolyl coumarin: A new class of blue light emitting fluorescent dyes

A library of novel 1, 2, 4-oxadiazole linked coumarin dyes have been synthesised via condensation of corresponding acid 6 and N’-hydroxybenzimidamide 8. This new class of organic compounds were examined for their fluorescent properties and found to emit blue light in the visible region of the spectrum with very high Stoke's shift values. Most of these compounds demonstrated high quantum yields and fluorescence life time in nano-second range which makes them quite lucrative to be used as new fluorescent probes. The highest quantum yield of 0.68 was shown by compound 9j which also shows high Stoke's shift value. The electronic structure of these coumarin-based donor–π–acceptor (D–π–A)-type organic dyes have been examined by Density Functional Theory (DFT). TGA analysis of few of the compounds show that they are stable up to temperature range of 0–245?°C. The synthesised compounds were characterised by NMR and mass spectrometry and the structure of two of these compounds have been confirmed by X-ray crystallography.

Semisynthesis, ex vivo evaluation, and SAR studies of coumarin derivatives as potential antiasthmatic drugs

Asthma is a chronic inflammatory disorder that causes contraction in the smooth muscle of the airway and blocking of airflow. Reversal the contractile process is a strategy for the search of new drugs that could be used for the treatment of asthma. This work reports the semisynthesis, ex vivo relaxing evaluation and SAR studies of a series of 18 coumarins. The results pointed that the ether derivatives 1-3, 7-9 and 13-15 showed the best activity (E max = 100%), where compound 2 (42 μM) was the most potent, being 4-times more active than theophylline (positive control). The ether homologation (methyl, ethyl and propyl) in position 7 or positions 6 and 7 of coumarins lead to relaxing effect, meanwhile formation of esters generated less active compounds than ethers. The SAR analysis showed that it is necessary the presence of two small ether groups and the methyl group at position 4 (site 3) encourage biological activity through soft hydrophobic changes in the molecule, without drastically affecting the cLogP.