87040-40-2

Basic information

• Product Name: (+/-)-N-methylpseudoephedrine
• Synonyms: (+/-)-N-methylpseudoephedrine
• CAS NO: 87040-40-2
• Molecular Weight: 179.262
• Mol File: 87040-40-2.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (+/-)-N-methylpseudoephedrine(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-N-methylpseudoephedrine(87040-40-2)
• EPA Substance Registry System: (+/-)-N-methylpseudoephedrine(87040-40-2)

Safety Data

• Hazardous Substances Data: 87040-40-2(Hazardous Substances Data)

Upstream product

• 90-82-4 pseudoephedrine 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 
• 17279-39-9 (S)-N,N-dimethyl-α-benzylethylamine 
• 35026-77-8 (S)-2-(dimethylamino)propiophenone 
• 66574-19-4 (4S,5S)-3,4-dimethyl-5-phenyl-1,3-oxazolidine 
• 492-39-7 (1S,2S)-2-amino-1-phenylpropanol 
• 26251-08-1 2-nitro-1-phenylpropan-1-ol 
• 6084-17-9 2-chloro-1-phenylpropan-1-one 
• 15351-09-4 metamfepramone 
• 299-42-3 (R,R)-(-)-pseudoephedrine 
• 67-68-5 dimethyl sulfoxide 
• 110073-16-0 2-(dimethylamino)-propionic acid N,N-dimethylamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 50-00-0 formaldehyd 
• 90-81-3 ephedrine 
• 100-52-7 benzaldehyde 
• 75-07-0 acetaldehyde 
• 124-40-3 dimethyl amine 
• 67-63-0 isopropyl alcohol 
• 108347-72-4 Dimethyl-[(1S,2S)-1-methyl-2-phenyl-2-((E)-1-trimethylsilanyloxy-propenyloxy)-ethyl]-amine 
• 98171-06-3 (2S,3R)-3-Hydroxy-2-methyl-3-phenyl-propionic acid (1S,2S)-2-dimethylamino-1-phenyl-propyl ester 
• 98171-06-3 (2S,3S)-3-Hydroxy-2-methyl-3-phenyl-propionic acid (1S,2S)-2-dimethylamino-1-phenyl-propyl ester 
• 98171-06-3 (2R,3R)-3-Hydroxy-2-methyl-3-phenyl-propionic acid (1S,2S)-2-dimethylamino-1-phenyl-propyl ester 
• 98171-06-3 (2R,3S)-3-Hydroxy-2-methyl-3-phenyl-propionic acid (1S,2S)-2-dimethylamino-1-phenyl-propyl ester 
• 98171-04-1 Dimethyl-[(1S,2S)-1-methyl-2-phenyl-2-((Z)-1-trimethylsilanyloxy-propenyloxy)-ethyl]-amine 
• 158837-63-9 (1S,2S)-1-Phenyl-1-phthalimido-2-(dimethylamino)propane 
• 2226-22-4 (1S,2S)-2-(Dimethylamino)-1-phenyl-1-(acetylthio)propane 

Relevant articles and documents

Enantioselective and Diastereoselective Construction of Chiral Amino Alcohols by Iridium-f-Amphox-Catalyzed Asymmetric Hydrogenation via Dynamic Kinetic Resolution

The iridium-f-amphox-catalyzed asymmetric hydrogenation of racemic α-amino β-unfunctionalized ketones proceeds via a DKR (dynamic kinetic resolution) process for the construction of various chiral N,N-disubstituted α-amino β-unfunctionalized alcohols in quantitative yields with excellent enantioselectivities and diastereoselectivities (all products >99% ee and >99:1 dr, TON up to 100 000). Importantly, this catalytic asymmetric hydrogenation with a DKR process provided a highly efficient and powerful synthetic strategy for the preparation of key chiral intermediates of the preclinical antitumor agent (S,S)-R116010.

1,2-Aminothioethers Derived from Ephedrine and Pseudoephedrine: Heterobidentate Ligands for the Palladium-Catalysed Asymmetric Allylic Substitution Reaction

Heterobidentate sulfide-tertiary amine ligands incorporating 1,2-aminothioethers derived from ephedrine and pseudoephedrine have been prepared and used successfully in the palladium-catalysed asymmetric allylic substitution reaction, giving ees of up to 89 percent. The stereoelectronic effects operating in the reactions are discussed.

The Reductive Cleavage of Cyclic Aminol Ethers to N,N-Dialkylamino-derivatives: Modifications to the Eschweiler-Clarke Procedure

The reductive cleavage of cyclic aminol ethers to give N-alkylamino-derivatives in very high yields can be achieved using chlorotrimethylsilane in the presence of sodium cyanoborohydride: in the case of cyclic aminol ethers derived from formaldehyde the Eschweiler-Clarke reaction can be carried out in formic acid heated under reflux in the absence of formaldehyde.