870653-45-5 Usage
Uses
5-(4-Phenoxybutoxy)psoralen (CAS# 870653-45-5) is a selective small molecule blocker of the lymphocyte K+ channel Kv1.3 and is used for the suppression of effector memory T cells in autoimmune diseases.
Biochem/physiol Actions
Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.
Check Digit Verification of cas no
The CAS Registry Mumber 870653-45-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,6,5 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 870653-45:
(8*8)+(7*7)+(6*0)+(5*6)+(4*5)+(3*3)+(2*4)+(1*5)=185
185 % 10 = 5
So 870653-45-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
870653-45-5Relevant articles and documents
5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel
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Page/Page column 4-5, (2008/06/13)
Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium
