870781-77-4

Basic information

• Product Name: 3-dimethylamino-1-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}propenone
• Synonyms: 3-dimethylamino-1-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}propenone
• CAS NO: 870781-77-4
• Molecular Weight: 335.857
• Mol File: 870781-77-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-dimethylamino-1-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}propenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-dimethylamino-1-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}propenone(870781-77-4)
• EPA Substance Registry System: 3-dimethylamino-1-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}propenone(870781-77-4)

Safety Data

• Hazardous Substances Data: 870781-77-4(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 1694-29-7 3-chloropentane-2,4-dione 
• 71047-49-9 1-(2-((4-chlorophenyl)amino)-4-methyl-1,3-thiazol-5-yl)ethan-1-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1333391-30-2 (4-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-m-tolylamine 
• 1333391-45-9 (4-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-(3-methoxyphenyl)amine 
• 1333391-53-9 (4-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-(4-fluorophenyl)amine 
• 1333391-27-7 (4-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-(3-chlorophenyl)amine 
• 1333391-23-3 (4-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-N-phenylamine 

Relevant articles and documents

Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro

A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by 1H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549. Thiazolyl-pyrimidines were synthesized by the general pyrimidine condensation of Bredereck and their in-vitro anticancer activities were evaluated. Copyright