87080-24-8

Basic information

• Product Name: 2-Methoxy-4-(O-prenyl)-4'-methoxymethoxychalcone
• Synonyms: 2-Methoxy-4-(O-prenyl)-4'-methoxymethoxychalcone
• CAS NO: 87080-24-8
• Molecular Weight: 382.456
• Mol File: 87080-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Methoxy-4-(O-prenyl)-4'-methoxymethoxychalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-4-(O-prenyl)-4'-methoxymethoxychalcone(87080-24-8)
• EPA Substance Registry System: 2-Methoxy-4-(O-prenyl)-4'-methoxymethoxychalcone(87080-24-8)

Safety Data

• Hazardous Substances Data: 87080-24-8(Hazardous Substances Data)

Upstream product

• 85699-00-9 1-[4-(methoxymethoxy)phenyl]-1-ethanone 
• 73569-44-5 2-methoxy-4-[(3-methylbut-2-en-1-yl)oxy]benzaldehyde 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 870-63-3 prenyl bromide 
• 61235-37-8 2-hydroxy-4-(3-methylbut-2-enyloxy)benzaldehyde 

Downstream Products

• 87080-26-0 4-Hydroxy-2-methoxy-4'-(methoxymethoxy)-5-(α,α-dimethylallyl)chalcone 
• 87080-27-1 licochalcone A 
• 87080-25-9 2-Methoxy-4-acetoxy-4'-(methoxymethoxy)-5-(α,α-dimethylallyl)chalcone 

Relevant articles and documents

Synthesis of Licochalcone-A

4,4'-Dihydroxy-2-methoxy-5-(α,α-dimethylallyl)chalcone (VII) (licochalcone-A) has been synthesised starting from β-resorcylaldehyde which on partial O-prenylation followed by methylation affords the aldehyde (II).The aldehyde (II) on condensation with p-methoxymethoxyacetophenone (III) under alkaline conditions affords the chalcone (IV), which on Claisen rearrangement yields the chalcone (V).Deacetylation and then demethoxymethylation of V by methanolic HCl affords licochalcone-A (VII), identical with a natural sample.