870849-56-2 Usage
General Description
1-(4-Fluoro-3-methoxyphenyl)ethan-1-ol is a chemical compound with the molecular formula C9H11FO2. It is an organic compound and belongs to the class of phenols. 1-(4-FLUORO-3-METHOXYPHENYL)ETHAN-1-OL is a colorless liquid at room temperature and is soluble in organic solvents. It is commonly used in the pharmaceutical and fragrance industries as a building block for the synthesis of other chemicals. Its chemical structure consists of a phenyl ring with a fluorine atom and a methoxy group attached to it, along with an ethan-1-ol group. 1-(4-FLUORO-3-METHOXYPHENYL)ETHAN-1-OL may have various applications in the production of pharmaceuticals, agrochemicals, and fragrances due to its unique chemical properties and structural features.
Check Digit Verification of cas no
The CAS Registry Mumber 870849-56-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,8,4 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 870849-56:
(8*8)+(7*7)+(6*0)+(5*8)+(4*4)+(3*9)+(2*5)+(1*6)=212
212 % 10 = 2
So 870849-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H11FO2/c1-6(11)7-3-4-8(10)9(5-7)12-2/h3-6,11H,1-2H3
870849-56-2Relevant articles and documents
Nucleophilic aromatic substitution of unactivated fluoroarenes enabled by organic photoredox catalysis
Nicewicz, David A.,Pistritto, Vincent A.,Schutzbach-Horton, Megan E.
, p. 17187 - 17194 (2020)
Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.
