870997-82-3 Usage
General Description
"3-(tert-Butoxycarbonylamino)-2-methoxyisonicotinic acid" is a chemical compound that belongs to the category of organic compounds known as isonicotinic acids. These compounds are characterized by a pyridine ring containing a carbonyl group at the 2-position and a carboxylic acid group at the 3-position. In this specific compound, the nitrogen on the pyridine ring is further substituted with a tert-butoxycarbonyl group, which is a protecting group often used in peptide synthesis. Additionally, a methoxy group is attached at the 2-position, contributing to its overall structure. As for its applications, detailed information is not readily available, which indicates that its usage might be specific to certain research contexts, such as in the development of pharmaceuticals or synthetic materials.
Check Digit Verification of cas no
The CAS Registry Mumber 870997-82-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,9,9 and 7 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 870997-82:
(8*8)+(7*7)+(6*0)+(5*9)+(4*9)+(3*7)+(2*8)+(1*2)=233
233 % 10 = 3
So 870997-82-3 is a valid CAS Registry Number.
InChI:InChI=1S/C12H16N2O5/c1-12(2,3)19-11(17)14-8-7(10(15)16)5-6-13-9(8)18-4/h5-6H,1-4H3,(H,14,17)(H,15,16)
870997-82-3Relevant articles and documents
Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors
Labadie, Sharada,Barrett, Kathy,Blair, Wade S.,Chang, Christine,Deshmukh, Gauri,Eigenbrot, Charles,Gibbons, Paul,Johnson, Adam,Kenny, Jane R.,Kohli, Pawan Bir,Liimatta, Marya,Lupardus, Patrick J.,Shia, Steven,Steffek, Micah,Ubhayakar, Savita,Abbema, Anne Van,Zak, Mark
, p. 5923 - 5930 (2013/10/22)
A highly ligand efficient, novel 8-oxo-pyridopyrimidine containing inhibitor of Jak1 and Jak2 isoforms with a pyridone moiety as the hinge-binding motif was discovered. Structure-based design strategies were applied to significantly improve enzyme potency and the polarity of the molecule was adjusted to gain cellular activity. The crystal structures of two representative inhibitors bound to Jak1 were obtained to enable SAR exploration.
