871329-82-7

Basic information

• Product Name: 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID
• Synonyms: 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID;3-FLUORO-5-HYDROXYPHENYLBORONIC ACID;B-(3-Fluoro-5-hydroxyphenyl)boronic acid;3-Borono-5-fluorophenol;3-Fluoro-5-hydroxyphenylboronic Acid (contains varying amounts of Anhydride);(3-Fluoro-5-hydroxyphenyl);3-Fluoro-5-hydroxybenzeneboronic
• CAS NO: 871329-82-7
• Molecular Formula: C₆H₆BFO₃
• Molecular Weight: 155.92
• Product Categories: blocks;BoronicAcids;FluoroCompounds
• Mol File: 871329-82-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 54-62
• Boiling Point: 380 °C at 760 mmHg
• Flash Point: 183.6 °C
• Appearance: /
• Density: 1.42
• Vapor Pressure: 1.89E-06mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.23±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID(871329-82-7)
• EPA Substance Registry System: 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID(871329-82-7)

Safety Data

• Hazardous Substances Data: 871329-82-7(Hazardous Substances Data)

Usage

Description

3-Fluoro-5-hydroxybenzeneboronic acid is an organic compound that features a boron atom bonded to a benzene ring with a hydroxyl and a fluorine substituent. This unique structure endows it with versatile chemical properties, making it a valuable building block in organic synthesis and a key intermediate in the pharmaceutical industry.
Used in Chemical Synthesis:
3-Fluoro-5-hydroxybenzeneboronic acid is used as a synthetic intermediate for the preparation of various organic compounds. Its boronic acid functionality allows it to participate in cross-coupling reactions, such as the Suzuki reaction, which is a powerful method for the formation of carbon-carbon bonds. This makes it a valuable component in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and advanced materials.
Used in Pharmaceutical Industry:
3-Fluoro-5-hydroxybenzeneboronic acid is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure can be incorporated into drug candidates to modulate their biological activity, selectivity, and pharmacokinetic properties. As a result, it plays a crucial role in the discovery and optimization of novel therapeutic agents for the treatment of various diseases and medical conditions.

InChI:InChI=1/C6H6BFO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9-11H

Upstream product

• 609807-25-2 3-fluoro-5-methoxyphenylboronic acid 

Downstream Products

• 1605328-91-3 (S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 
• 1604800-77-2 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(3-(methylsulfinyl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 
• 1604800-78-3 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(3-(methylsulfinyl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 
• 1604800-74-9 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(3-(methylthio)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 
• 1604800-93-2 (S)-2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(1-phenylethyl)pyrrolo[2,1-f][ 1,2,4]triazin-4(3H)-one 
• 1604800-72-7 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 
• 1417792-49-4 C₃₅H₃₄ClFN₄O₉S 
• 1417792-48-3 C₁₈H₁₉FN₂O₅ 
• 1417792-47-2 C₁₅H₁₂FNO₅ 
• 1417792-46-1 C₁₉H₂₀FNO₅ 
• 1417792-20-1 C₃₃H₃₁ClFN₃O₉S 
• 1417792-37-0 C₃₅H₃₅ClFN₃O₉S 
• 1417792-36-9 C₂₆H₂₈ClFN₂O₆ 
• 1417792-35-8 C₂₆H₂₆ClFN₂O₈ 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

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