871727-05-8

Basic information

• Product Name: 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE)
• Synonyms: 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE);3. 6-[(tert-Butoxy)carbonyl]-6-a7.aspiro[2 5]octane- l -carboxyl ic acid;6-Boc-6-azaspiro[2.5]octane-1-carboxylic Acid;6-Azaspiro[2.5]octane-1,6-dicarboxylic acid, 6-(1,1-dimethylethyl) ester;6-azaspiro[2.5]octane-1-carboxylic acid;6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1,6-dicarboxylic acid;6-[(2-methylpropan-2-yl)oxycarbonyl]-6-azaspiro[2.5]octane-2-carboxylic acid;6-(tert-butoxycarbonyl)-6-azaspiro 2.5 octane-1-carboxylic acid(SALTDATA
• CAS NO: 871727-05-8
• Molecular Formula: C₁₃H₂₁NO₄
• Molecular Weight: 191.65526
• Mol File: 871727-05-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 392.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.71±0.20(Predicted)
• CAS DataBase Reference: 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE)(871727-05-8)
• EPA Substance Registry System: 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE)(871727-05-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 871727-05-8(Hazardous Substances Data)

Usage

General Description

6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid is a chemical compound with the molecular formula C13H23NO5. It is commonly used in the synthesis of pharmaceuticals and other organic compounds. 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE) is a derivative of azaspiro compounds and contains a tert-butoxycarbonyl group, which makes it useful for protecting various functional groups in organic synthesis. It is also a carboxylic acid, indicating that it has acidic properties and can form salts with bases. Due to its versatile applications in organic chemistry, it is an important chemical in the pharmaceutical and research industries.

Upstream product

• 1242268-17-2 6-(tert-butyl) 1-ethyl 6-azaspiro[2.5]octane-1,6-dicarboxylate 
• 871727-04-7 6-tert-butyl 1-methyl 6-azaspiro[2.5]octane-1,6-dicarboxylate 

Downstream Products

• 1453272-51-9 tert-butyl 1-[[(1S)-1-phenylethyl]carbamoyl]-6-azaspiro[2.5]octane-6-carboxylate 
• 1453472-65-5 tert-butyl (1S)-1-([[(1S)-1-phenylethyl]amino]methyl)-6-azaspiro[2,5]octane-6-carboxylate 
• 1453272-50-8 tert-butyl (1S)-1-[[(1S)-1-phenylethyl]carbamoyl]-6-azaspiro[2.5]octane-6-carboxylate 

Relevant articles and documents

COMBINATIONS COMPRISING BENZODIOXOL AS GLP-1R AGONISTS FOR USE IN THE TREATMENT OF NASH/NAFLD AND RELATED DISEASES

In part, the invention provides a new combination comprising (1) a GLP-1R agonist and (2) an ACC inhibitor or a DGAT2 inhibitor, or a KHK inhibitor or FXR agonist. The invention further provides new methods for treating diseases and disorders, for example, fatty liver, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, nonalcoholic steatohepatitis with liver fibrosis, nonalcoholic steatohepotitis with cirrhosis, and nonalcoholic steatohepatitis with cirrhosis and with hepatocellular carcinoma or with a metabolic-related disease, obesity, and type 2 diabetes, for example, using the new combination described herein.

GLP-1 RECEPTOR AGONISTS AND USES THEREOF

Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza- benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES

Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.