872857-74-4Relevant articles and documents
5-Carba-pterocarpens: A new scaffold with anti-HCV activity
Fernandes, Talita de A.,Costa, Paulo R. R.,Manvar, Dinesh,Basu, Amartya,Kaushik-Basu, Neerja,Domingos, Jorge L. O.,Nichols, Daniel Brian
, p. 33 - 38 (2018/05/15)
The synthesis of a series of 5-carba-pterocarpens derivatives involving the cyclization of α-aryl-α-tetralones is described. Several compounds demonstrated potent activity and selectivity in vitro against HCV replicon reporter cells. The best profile in H
Synthesis of 5-carbapterocarpens by α-arylation of tetralones followed by one-pot demethylation/cyclization with BBr3
Fernandes, Talita De A.,Domingos, Jorge L. O.,Da Rocha, Luiza I. A.,De Medeiros, Sabrina,Najera, Carmen,Costa, Paulo R. R.
, p. 1314 - 1320 (2014/03/21)
5-Carbapterocarpens, one of them displaying estrogenic activity, were prepared from α-aryltetralones in high yields through a one-pot, BBr 3-promoted O-demethylation and cyclization sequence. The key α-aryltetralone intermediates were obtained
Tetracyclic compounds as estrogen ligands
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Page/Page column 11; 16, (2010/02/15)
This invention provides estrogen receptor modulators having the structure: wherein R1, R2, R3, R4, Q, n, R8, R9, R10, and R11 have been defined in the specification; o