873331-73-8

Basic information

• Product Name: Pyrimidine, 5-bromo-2-ethyl- (9CI)
• Synonyms: Pyrimidine, 5-bromo-2-ethyl- (9CI);5-Bromo-2-ethylpyrimidine;PyriMidine, 5-broMo-2-ethyl-;5-Bromo-2-ethyl-pyrimidin
• CAS NO: 873331-73-8
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.03718
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 873331-73-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 211.751 °C at 760 mmHg
• Flash Point: 81.864 °C
• Appearance: /
• Density: 1.498 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.56±0.22(Predicted)
• CAS DataBase Reference: Pyrimidine, 5-bromo-2-ethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 5-bromo-2-ethyl- (9CI)(873331-73-8)
• EPA Substance Registry System: Pyrimidine, 5-bromo-2-ethyl- (9CI)(873331-73-8)

Safety Data

• Hazardous Substances Data: 873331-73-8(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 5-bromo-2-ethyl- (9CI) is a chemical compound with the molecular formula C7H8BrN2. It is a derivative of pyrimidine, a heterocyclic organic compound found in nature as a component of DNA and RNA. The 5-bromo-2-ethyl substitution in this compound makes it a potentially useful intermediate for the synthesis of pharmaceuticals and agrochemicals. It is also used in research and development as a building block for the synthesis of various biologically active compounds. Pyrimidine, 5-bromo-2-ethyl- (9CI) may have potential applications in the pharmaceutical and agricultural industries, as well as in academic research.

Upstream product

• 60544-11-8 2-ethyl-pyrimidine 
• 557-20-0 diethylzinc 
• 183438-24-6 5-bromo-2-iodopyrimidine 
• 1235450-86-8 5-bromo-2-ethylpyrimidine-4-carboxylic acid 
• 32779-36-5 5-Bromo-2-chloropyrimidine 

Downstream Products

• 1083329-21-8 2-ethyl-5-benzyloxypyrimidine 
• 1351167-69-5 (S)-1-(1-(2-ethylpyrimidin-5-yl)piperidin-4-yl)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)pyrrolidin-2-one 
• 1172612-64-4 C₁₅H₁₄N₂ 
• 1172612-62-2 C₁₄H₁₂N₂ 
• 1172612-63-3 C₁₅H₁₄N₂ 
• 1072855-08-3 (3S)-N,N-dibenzyl-5-(2-ethylpyrimidin-5-yl)chroman-3-amine 

Relevant articles and documents

Preparation method of 2-ethyl-5-(piperidine-4-yl)pyrimidine

The invention discloses a preparation method of 2-ethyl-5-(piperidine-4-yl)pyrimidine. A target product is obtained by taking 2-ethyl pyrimidine as a starting raw material through bromine feeding, coupling, elimination and catalytic hydrogenation reaction. The compound is an important medicine intermediate.

SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF

Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.

TREATMENT OF CANCERS HAVING K-RAS MUTATIONS

The present invention provides a method of treating a cancer associated with a K- ras mutation in a subject in need thereof. The method comprises the steps of (1) identifying a subject with a cancer associated with a K-ras mutation; and (2) adminsiterign to the subject (i) an inhibitor of PI3 kinase and (ii) an HDAC inhibitor, wherein the PI3 kinase inhibitor and the HDAC inhibitor are administered in amounts which together are therapeutically effective.