875-66-1Relevant articles and documents
Novel 4-(1H-1,2,3-triazol-4-yl)methoxy)cinnolines as potent antibacterial agents: Synthesis and molecular docking study
Boda, Sathish Kumar,Bommagani, Mohan Babu,Chitneni, Prasad Rao,Mokenapelli, Sudhakar,Yerrabelli, Jayaprakash Rao
, (2020/03/04)
A new series of cinnoline-1,2,3-triazole derivatives were designed and synthesized by adopting Cu(1) catalyzed regeoselective1,3-dipolar cycloaddition reaction of terminal alkyne and azide. The in vitro antibacterial activity of all these compounds revealed that compounds 9d, 10a, 10b, and 10c are more potent antibacterial agents. Among the series, compound 4-(3-(4-((cinnolin-4-yloxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)morpholine (10b) exhibited the most potent antibacterial activity against all tested gram-positive and gram-negative bacterial strains. Furthermore, molecular docking studies were also performed to understand the binding interactions of the most active analogs 9d, 10a, 10b, and 10c with Elastase of Pseudomonas aeruginosa (PDB: 1U4G). The results indicated that these classes of compounds have potential antibacterial activity, especially the compound 10b may serve as a promising antibacterial lead compound that could be further optimized for the further development of antibacterial drugs.
4-Aminoquinolone piperidine amides: Noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity
Naik, Maruti,Humnabadkar, Vaishali,Tantry, Subramanyam J.,Panda, Manoranjan,Narayan, Ashwini,Guptha, Supreeth,Panduga, Vijender,Manjrekar, Praveena,Jena, Lalit Kumar,Koushik, Krishna,Shanbhag, Gajanan,Jatheendranath, Sandesh,Manjunatha,Gorai, Gopinath,Bathula, Chandramohan,Rudrapatna, Suresh,Achar, Vijayashree,Sharma, Sreevalli,Ambady, Anisha,Hegde, Naina,Mahadevaswamy, Jyothi,Kaur, Parvinder,Sambandamurthy, Vasan K.,Awasthy, Disha,Narayan, Chandan,Ravishankar, Sudha,Madhavapeddi, Prashanti,Reddy, Jitendar,Prabhakar,Saralaya, Ramanatha,Chatterji, Monalisa,Whiteaker, James,McLaughlin, Bob,Chiarelli, Laurent R.,Riccardi, Giovanna,Pasca, Maria Rosalia,Binda, Claudia,Neres, Jo?o,Dhar, Neeraj,Signorino-Gelo, Fran?ois,McKinney, John D.,Ramachandran, Vasanthi,Shandil, Radha,Tommasi, Ruben,Iyer, Pravin S.,Narayanan, Shridhar,Hosagrahara, Vinayak,Kavanagh, Stefan,Dinesh, Neela,Ghorpade, Sandeep R.
supporting information, p. 5419 - 5434 (2014/07/08)
4-Aminoquinolone piperidine amides (AQs) were identified as a novel scaffold starting from a whole cell screen, with potent cidality on Mycobacterium tuberculosis (Mtb). Evaluation of the minimum inhibitory concentrations, followed by whole genome sequencing of mutants raised against AQs, identified decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) as the primary target responsible for the antitubercular activity. Mass spectrometry and enzyme kinetic studies indicated that AQs are noncovalent, reversible inhibitors of DprE1 with slow on rates and long residence times of ～100 min on the enzyme. In general, AQs have excellent leadlike properties and good in vitro secondary pharmacology profile. Although the scaffold started off as a single active compound with moderate potency from the whole cell screen, structure-activity relationship optimization of the scaffold led to compounds with potent DprE1 inhibition (IC50 10 nM) along with potent cellular activity (MIC = 60 nM) against Mtb.
Solid-phase synthesis of substituted cinnolines by a Richter type cleavage protocol
Braese, Stefan,Dahmen, Stefan,Heuts, Jean
, p. 6201 - 6203 (2007/10/03)
Starting from triazene bound ortho-halo arenes on a solid support, palladium-catalyzed alkynylations and subsequent cleavage reactions under acidic conditions give rise to ortho-alkynylaryldiazonium salts, which in turn undergo cyclization to afford substituted 4-halo- and 4- hydroxycinnolines in moderate to good yields. The method is applicable to automated synthesis.
