875003-43-3

Basic information

• Product Name: 7-fluoro-1-Methyl-1H-Indole-2,3-dione
• Synonyms: 7-fluoro-1-Methyl-1H-Indole-2,3-dione;7-Fluoro-1-methylindoline-2,3-dione;7-fluoro-1-methylisatin
• CAS NO: 875003-43-3
• Molecular Formula: C₉H₆FNO₂
• Molecular Weight: 179.1478432
• Product Categories: intermediates
• Mol File: 875003-43-3.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-fluoro-1-Methyl-1H-Indole-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-fluoro-1-Methyl-1H-Indole-2,3-dione(875003-43-3)
• EPA Substance Registry System: 7-fluoro-1-Methyl-1H-Indole-2,3-dione(875003-43-3)

Safety Data

• Hazardous Substances Data: 875003-43-3(Hazardous Substances Data)

Usage

General Description

7-fluoro-1-Methyl-1H-Indole-2,3-dione, also known as 7-fluoro-1-methylindole-2,3-dione, is a chemical compound with the molecular formula C9H6FNO2. It is a fluorescent yellow solid that is used in various organic synthesis reactions, particularly in the pharmaceutical industry. 7-fluoro-1-Methyl-1H-Indole-2,3-dione is a derivative of indole, a heterocyclic aromatic organic compound, and its fluoro and methyl substituents make it useful in the formation of diverse organic molecules and pharmaceutical drugs. Its unique structure and properties make it a valuable building block for the synthesis of a variety of advanced materials and biologically active compounds.

Upstream product

• 317-20-4 7-fluoro-1H-indole-2,3-dione 
• 77-78-1 dimethyl sulfate 
• 349-24-6 N-(2-fluorophenyl)-2-(hydroxyimino)acetamide 
• 74-88-4 methyl iodide 
• 349-24-6 N-(2-Fluorophenyl)-2-hydroxyiminoacetamide 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 1643583-06-5 C₃₇H₃₆FNO₄Si 
• 1643582-74-4 C₃₁H₂₂FNO₄ 
• 1443041-78-8 (2S,5S)-dibenzhydryl 7'-fluoro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate 
• 1407968-09-5 C₁₅H₁₁FN₂O₂ 
• 1080671-56-2 C₃₄H₄₃FN₃O₆PSi 

Relevant articles and documents

Base-mediated allylation of N-2,2,2-trifluoroethylisatin ketimines and its application in aza-Prins reactions

The aza-Prins reaction of allylic imines triggered by N-2,2,2-trifluoroethylisatin ketimine is accomplished for the synthesis of spirooxindole derivatives involving trifluoromethyl group in the presence of TMSX. This cyclization reaction is operationally simple and proceeds under mild conditions using non-toxic reagents. Notably, while the previous our work could not be compatible with TMSX (X = Cl, I, etc) in one-pot process, this work describes successful aza-Prins reaction with TMSX (X = Cl, I, etc) via step-by-step process.

Palladium-Catalyzed Allylation of Cyclopropyl Acetylenes with Oxindoles to Construct 1,3-Dienes

A novel palladium-catalyzed allylic alkylation of oxindoles with cyclopropyl acetylenes has been developed. Various 1,3-diene oxindole framework bearing a quaternary stereocenter at the C3 position were synthesized straightforwardly in good to excellent yields with high regio-, and stereoselectivities. The reaction exhibited high atom economy and good functional group tolerance.

Efficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)-Catalyzed C?H Activation/Carbene Insertion/Lossen Rearrangement Sequence

A rhodium(III)-catalyzed domino annulation of simple olefins with diazo oxindoles to give spirooxindole pyrrolone products is described. This reaction can be formally viewed as the result of an anomalous tandem C?H activation, carbene insertion, Lossen rearrangement, and a nucleophilic addition process. The potential utility of this reaction was further demonstrated by the late-stage diversification of drug molecules.