875637-14-2

Basic information

• Product Name: Phenol, 3-(3-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-
• CAS NO: 875637-14-2
• Molecular Formula: C19H14N2O
• Molecular Weight: 286.333
• Mol File: 875637-14-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phenol, 3-(3-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 3-(3-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-(875637-14-2)
• EPA Substance Registry System: Phenol, 3-(3-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-(875637-14-2)

Safety Data

• Hazardous Substances Data: 875637-14-2(Hazardous Substances Data)

Upstream product

• 1492681-33-0 3-phenyl-5-(3-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine 
• 757978-18-0 3-iodo-5-bromo-1H-pyrrolo[2,3-b]-pyridine 
• 1492680-54-2 3-phenyl-5-(3-methoxyphenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 757978-19-1 5-bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

3,5-Diarylazaindoles as DYRK1A Protein Inhibitors for the Treatment of Cognitive Deficiencies Associated with Down's Syndrome and with Alzheimer's Disease

The present invention relates to a compound of formula (I′) or a pharmaceutically acceptable salt, solvate or hydrate thereof, in which: X3 is F, OH or SH, Y3 is F, OH or SH, X1, X2, X4, X5, Y1, Y2, Y4 and Y5 are, independently of one another, H, F, Cl, Br, OH or SH, and 1 to 2 groups among the X1, X2, X4 and X5 radicals are other than H and/or 1 to 2 groups among the Y1, Y2, Y4 and Y5 radicals are other than H. The present invention also relates to a compound of formula (I′) for use as a medicament, in particular in the prevention and/or treatment of cognitive disorders associated with a dysfunction of the Dyrk1A protein.

PYRROLO-PYRIDINE KINASE MODULATORS

The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.