87578-99-2

Basic information

• Product Name: safracin B
• Synonyms: safracin B;2-Amino-N-[(6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-epimino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]propionamide
• CAS NO: 87578-99-2
• Molecular Formula: C28H36N4O7
• Molecular Weight: 540.613
• Mol File: 87578-99-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 755.1°C at 760 mmHg
• Flash Point: 410.4°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 5.89E-24mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: -20°C
• Solubility: Soluble in DMSO (up to 20 mg/ml)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: safracin B(CAS DataBase Reference)
• NIST Chemistry Reference: safracin B(87578-99-2)
• EPA Substance Registry System: safracin B(87578-99-2)

Safety Data

• Hazardous Substances Data: 87578-99-2(Hazardous Substances Data)

Usage

Description

Safracin B, with the chemical formula C35H38N4O7 and the molecular weight of 662.71 g/mol, is a novel antibiotic belonging to the saframycin family. It is produced by Pseudomonas fluorescens, a species of bacteria known for its biocontrol and biofertilizer properties. Safracin B exhibits significant antitumor activity and has a lower toxicity compared to other members of the saframycin family, such as safracin A.

Uses

Used in Pharmaceutical Industry:
Safracin B is used as an antitumor agent for its ability to effectively target and combat various types of cancer cells. It has demonstrated potent activity against L1210 and P388 leukemias, as well as B16 melanoma, showcasing its potential as a promising candidate for cancer treatment.
Furthermore, Safracin B is used to enhance the life expectancy of tumor-bearing mice, indicating its potential to improve the quality of life for cancer patients by prolonging survival rates and reducing the severity of the disease.

References

1) Ikeda?et al.?(1983),?Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation; J. Antibiot. Tokyo,?36?1279 2) Okumoto?et al. (1985),?Activity of safracins A and B, heterocyclic quinone antibiotics, on experimental tumors in mice; J. Antibiot.Tokyo,?38?767

InChI:InChI=1/C28H36N4O7/c1-11-7-14-8-17-28(37)32-16(21(31(17)4)19(14)23(34)25(11)38-5)9-15-20(18(32)10-30-27(36)13(3)29)24(35)26(39-6)12(2)22(15)33/h7,13,16-18,21,28,34,37H,8-10,29H2,1-6H3,(H,30,36)/t13-,16-,17+,18-,21+,28-/m0/s1

Downstream Products

• 308359-16-2 C₃₆H₄₀N₆O₆S