87597-26-0

Basic information

• Product Name: 5-BROMOIMIDAZO[1,2-A]PYRAZINE
• Synonyms: 5-BROMOIMIDAZO[1,2-A]PYRAZINE;5-BroMo-2,3-dihydroiMidazo[1,2-a]pyrazine
• CAS NO: 87597-26-0
• Molecular Formula: C₆H₄BrN₃
• Molecular Weight: 198.02
• Product Categories: Halides;Pyrazine;Fused Ring Systems
• Mol File: 87597-26-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 385.299 °C at 760 mmHg
• Flash Point: 186.823 °C
• Appearance: /
• Density: 1.706 g/cm³
• Refractive Index: 1.751
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.65±0.30(Predicted)
• CAS DataBase Reference: 5-BROMOIMIDAZO[1,2-A]PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMOIMIDAZO[1,2-A]PYRAZINE(87597-26-0)
• EPA Substance Registry System: 5-BROMOIMIDAZO[1,2-A]PYRAZINE(87597-26-0)

Safety Data

• Hazardous Substances Data: 87597-26-0(Hazardous Substances Data)

Usage

General Description

5-BROMOIMIDAZO[1,2-A]PYRAZINE is a chemical compound with the molecular formula C5H3BrN2. It is a heterocyclic compound containing both imidazole and pyrazine rings. 5-BROMOIMIDAZO[1,2-A]PYRAZINE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of other organic compounds. 5-BROMOIMIDAZO[1,2-A]PYRAZINE is known for its high reactivity and versatility, making it a valuable compound in the field of organic chemistry. However, it should be handled with care, as it may pose health and environmental hazards.

InChI:InChI=1/C6H4BrN3/c7-5-3-8-4-6-9-1-2-10(5)6/h1-4H

Upstream product

• 274-79-3 imidazo[1,2-a]pyrazine 

Relevant articles and documents

Visible-light-promoted oxidative halogenation of (hetero)arenes

Organic halides are critical building blocks that participate in various cross-coupling reactions. Furthermore, they widely exist as natural products and artificial molecules in drugs with important physiological activities. Although halogenation has been well studied, to the best of our knowledge, studies focussing on sensitive systems (e.g.aryl amines) have not been reported. Herein, we describe a compatible oxidative halogenation of (hetero)arenes with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure). Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application.

Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization

An efficient and practical system for inexpensive bromination and iodination of arenes as well as heteroarenes by using readily available dimethyl sulfoxide (DMSO) and HX (X = Br, I) reagents is reported. This mild oxidative system demonstrates a versatile protocol for the synthesis of aryl halides. HX (X = Br, I) are employed as halogenating reagents when combined with DMSO which participates in the present chemistry as a mild and inexpensive oxidant. This oxidative system is amenable to late-stage bromination of natural products. The kilogram-scale experiment (>95% yield) shows great potential for industrial application.

Imidazopyrazine, Bromo and Methoxy Derivatives: a 13C N.M.R. Determination Applied to Nucleophilic Substitution Studies

The 13C chemical shifts and coupling constants of imidazopyrazine and some of its derivatives are reported and compared with those of other series.These data enable us to study the nucleophilic substitution of 3,5-dibromoimidazopyrazine and 6,8-dibromoimidazopyrazine by a methoxy group.