876-72-2

Basic information

• Product Name: 4-Chloroindole-3-carbaldehyde
• Synonyms: 4-CHLOROINDOLE-3-CARBALDEHYDE;4-CHLOROINDOLE-3-CARBOXALDEHYDE;4-CHLORO-1H-INDOLE-3-CARBALDEHYDE;4-Chloro-1H-indole-3-carboxaldehyde 98%;4-CHLOROINDOLE-3-CARBOXALDEHYDE 98%;4-Chloro-1H-indole-3-carboxaldehyde
• CAS NO: 876-72-2
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.6
• Product Categories: Indole
• Mol File: 876-72-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 164 °C
• Boiling Point: 373.4 °C at 760 mmHg
• Flash Point: 179.6 °C
• Appearance: /
• Density: 1.431 g/cm³
• Vapor Pressure: 8.99E-06mmHg at 25°C
• Refractive Index: 1.731
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.60±0.30(Predicted)
• CAS DataBase Reference: 4-Chloroindole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloroindole-3-carbaldehyde(876-72-2)
• EPA Substance Registry System: 4-Chloroindole-3-carbaldehyde(876-72-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 876-72-2(Hazardous Substances Data)

Usage

General Description

4-Chloroindole-3-carbaldehyde is a chemical compound that belongs to the indole family of organic compounds. It is a pale yellow solid at room temperature and is most commonly used as an intermediate in the synthesis of other organic compounds. This chemical is used in the pharmaceutical industry as a building block for the preparation of various drugs and can also be used in organic synthesis to create more complex molecules. 4-Chloroindole-3-carbaldehyde has been studied for its potential biological and pharmacological properties, making it an important compound in medicinal chemistry research. It is important to handle and store this chemical with care, as it can be hazardous if not properly managed.

InChI:InChI=1/C9H6ClNO/c10-7-2-1-3-8-9(7)6(5-12)4-11-8/h1-5,11H

Upstream product

• 43142-77-4 ethyl 4-chloro-3-formyl-1H-indole-2-carboxylate 
• 487-89-8 Indole-3-carboxaldehyde 
• 25235-85-2 4-chloro-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 
• 53590-46-8 4-chloro-1H-indole-2-carboxylic acid ethyl ester 
• 101909-42-6 methyl 4-chloro-1H-indole-3-carboxylate 
• 942-24-5 3-methoxycarbonylindole 

Downstream Products

• 2447-16-7 2-(4-chloro-1H-indol-3-yl)ethanamine 
• 858236-14-3 4-chloro-3-methyl-1H-indole 
• 889942-73-8 4-Chloro-1H-indole-3-carbonitrile 
• 1428968-37-9 1-(4-chloro-1H-indol-3-yl)-2-((3-methoxyphenyl)amino)-2-phenylethanone 
• 1422432-57-2 C₂₁H₁₆ClN₃O₃ 
• 1422433-20-2 C₂₃H₂₀ClN₃O₃ 
• 101909-42-6 methyl 4-chloro-1H-indole-3-carboxylate 

Relevant articles and documents

Access to Polycyclic Thienoindolines via Formal [2+2+1] Cyclization of Alkynyl Indoles with S8and K2S

The syntheses of polycyclic thienoindolines bearing a dihydrothiophene or tetrahydrothiophene subunit have not been reported, despite the fact that such compounds may have interesting medicinal properties. Herein, we report a protocol for accessing polycyclic dihydrothiophenes by means of formal [2+2+1] intramolecular dearomatizing cyclization of alkynyl indoles with K2S and S8 as the sources of sulfide. In addition, tetrahydrothienoindolines were stereoselectively synthesized via a one-pot, two-step protocol involving AgNO3-catalyzed alkenyl dearomatization followed by two nucleophilic addition reactions involving K2S.

Synthesis of polycyclic spirooxindoles via an asymmetric catalytic one-pot stepwise Aldol/chloroetherification/aromatization procedure

A general method for the synthesis of chiral pentacyclic spirooxindoles containing a tetrahydropyrano[2,3-b]indole scaffold through a one-pot stepwise sequence from 3-(3-indolomethyl)oxindole, paraformaldehyde and NCS is reported. Furthermore, the pentacyclic spirooxindoles could be transformed to bispirooxindole and other structurally diverse spirocyclic oxindoles.

HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R3c, R4a, R4b, R5, R6, Z and X are as defined herein are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.