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87680-15-7

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87680-15-7 Usage

Synthetic derivative

A chemical compound that is created through artificial synthesis, as opposed to being naturally occurring.

Vitamin D

A group of fat-soluble secosteroids that play a key role in the regulation of calcium and phosphate metabolism, and are essential for bone health.

Biological activities

The various ways in which a substance interacts with living organisms, including its effects on cellular processes and physiological functions.

Potent agonist

A substance that binds to a receptor and produces a strong biological response, in this case, activating the vitamin D receptor.

Vitamin D receptor

A protein that binds to vitamin D and mediates its effects on target cells.

Regulation of calcium and phosphate metabolism

The process by which the body maintains the balance of calcium and phosphate, which are essential for bone formation and other physiological functions.

Modulation of immune function

The ability of a substance to influence the activity of the immune system, either by enhancing or suppressing its response.

Potential anti-cancer effects

The possibility that a substance may have the ability to prevent or slow the growth of cancer cells.

Autoimmune diseases

A group of disorders in which the immune system mistakenly attacks the body's own tissues, leading to inflammation and damage.

Chronic kidney disease

A condition characterized by the gradual loss of kidney function over time, which can lead to a buildup of waste products in the body and other complications.

Therapeutic potential

The possibility that a substance may be used to treat or manage a particular disease or condition.

Check Digit Verification of cas no

The CAS Registry Mumber 87680-15-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,6,8 and 0 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 87680-15:
(7*8)+(6*7)+(5*6)+(4*8)+(3*0)+(2*1)+(1*5)=167
167 % 10 = 7
So 87680-15-7 is a valid CAS Registry Number.

87680-15-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S,5R)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Dihydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-hydroxy-3-methyl-dihydro-furan-2-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:87680-15-7 SDS

87680-15-7Upstream product

87680-15-7Downstream Products

87680-15-7Relevant articles and documents

Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25

Nagata, Akiko,Akagi, Yusuke,Masoud, Shadi Sedghi,Yamanaka, Masahiro,Kittaka, Atsushi,Uesugi, Motonari,Odagi, Minami,Nagasawa, Kazuo

, p. 7630 - 7641 (2019/05/16)

(23S,25R)-Calcitriol lactone is a major metabolite of vitamin D3, but its synthesis has been far less well investigated than that of 1α,25(OH)2 vitamin D3, the active form of vitamin D3, even though the lactone

Facile Stereoselective Synthesis of (23S,25R)-1α,25-Dihydroxyvitamin D3 26,23-Lactone, a Major Metabolite of 1α,25-Dihydroxyvitamin D3

Yamamoto, Keiko,Shimizu, Masato,Yamada, Sachiko,Iwata, Suguru,Hoshino, Osamu

, p. 33 - 39 (2007/10/02)

(23S,25R)-1α,25-Dihydroxyvitamin D3 26,23-lactone (1a), a major metabolite of 1α,25-dihydroxyvitamin D3 2, was synthesized efficiently and stereoselectively from 1α-hydroxydehydroepiandrosterone (3).The 17-oxosteroid 3 was first converted to C(22)-steroid aldehyde 9 with the natural stereochemistry at C(17) and C(20) using a stereoselective ene reaction as the key step.Then it was combined with the chiral C5 sulfone 4 having the correct stereochemistry for the lactone in 1a.Sulfone 4 was readily obtained from commercially available (R)-citramalic acid.The side-chain lactone with the natural stereochemistry at C(23) was constructed with high stereoselectivity (84percent) by iodo lactonization of the Δ22-26-carboxylic acid 16b under kinetically controlled conditions in the presence of γ-collidine.The stereoselectivity of the iodo lactonization of steroidal Δ22-25-hydroxy-26-carboxylic acids 16b, 24, and 25 was studied in detail, and a mechanism is proposed in which the configuration at C(25) and an added pyridine base play an important role.

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