87691-91-6

Basic information

• Product Name: Tiospirone
• Synonyms: 8-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione;MJ-13859;87691-92-7 (Hydrochloride);8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-;Tiospirona;Tiospirona [spanish];Tiospirone [inn];Tiospironum
• CAS NO: 87691-91-6
• Molecular Formula: C₂₄H₃₂N₄O₂S
• Molecular Weight: 440.6
• Mol File: 87691-91-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 600.9°C at 760 mmHg
• Flash Point: 317.2°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 2.13E-14mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: Tiospirone(CAS DataBase Reference)
• NIST Chemistry Reference: Tiospirone(87691-91-6)
• EPA Substance Registry System: Tiospirone(87691-91-6)

Safety Data

• Hazardous Substances Data: 87691-91-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C24H32N4O2S/c29-21-17-24(9-3-4-10-24)18-22(30)28(21)12-6-5-11-26-13-15-27(16-14-26)23-19-7-1-2-8-20(19)31-25-23/h1-2,7-8H,3-6,9-18H2

Upstream product

• 21098-11-3 8-(4-chlorobutyl)-8-azaspiro<4.5>decane-7,9-dione 
• 87691-87-0 3-(1-piperazinyl)-1,2-benzisothiazole 
• 1075-89-4 tetramethylene glutarimide 
• 87691-94-9 8-(1,2-benzisothiazol-3-yl)-8-aza-5-azoniaspiro[4.5]decane bromide 
• 80827-62-9 8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione 
• 2634-33-5 1,2-benzisothiazolin-3-one 
• 7716-66-7 3-chloro-1,2-benzisothiazole 
• 19602-82-5 2,2'-dithiodibenzoic acid dichloride 
• 3950-02-5 2-chlorosulfenylbenzoyl chloride 
• 119-80-2 2,2'-dithiobenzoic acid 

Downstream Products

• 131779-62-9 8-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>butyl>-6-<<<(4-nitrobenzyl)oxy>carbonyl>oxy>-8-azaspiro<4.5>decane-7,9-dione 

Relevant articles and documents

Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis

The present invention relates to a method of treating depression, obsessive compulsive disorder and psychosis in a mammal, including a human, by administering to the mammal an atypical antipsychotic in combination with an antidepressant agent with improvement in efficiency. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier, an atypical antipsychotic, and an SRI.

Benzisothiazole and benzisoxazole piperazine derivatives

Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is benzisothiazol-3-yl or benzisoxazol-3-yl and the other is alkylene attached to heterocycles such as azaspiro[4.5]decanedione, dialkylglutarimide, thiazolidinedione and spirocyclopentylthiazolidinedione or butyrophenone-like groups. The compounds have psychotropic properties and 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspior[4.5]decane-7,9-dione is a typical embodiment having selective antipsychotic activity.