87692-35-1Relevant articles and documents
Synthesis of Aromatic Modified Prostaglandins from PGA2
Cai, Zuyun,Nassium, Bahman,Crabbe, Pierre
, p. 1573 - 1578 (2007/10/02)
A general synthetic scheme, starting from PGA2 (obtained from the marine coral Plexaura homomalla), of prostaglandins modified in the upper chain is detailed.Key aldehyde intermediates have been secured from 11-deoxy-PGF2α and PGF2α by an efficient regioselective hydroxylation procedure followed by cleavage of the 5,6-double bond.Witting reaction with these aldehydes provided the novel prostaglandins (5)-(8), belonging to the E and F families, and containing an aromatic ring in the upper chain.