878905-11-4

Basic information

• Product Name: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-(METHYLSULFONYLOXY)HEXANOATE
• Synonyms: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-(METHYLSULFONYLOXY)HEXANOATE;tert-Butyl 2-(tert-butoxycarbonylamino)-6-(methanesulfonyloxy)hexanoate
• CAS NO: 878905-11-4
• Molecular Formula: C₁₆H₃₁NO₇S
• Molecular Weight: 381.487
• Mol File: 878905-11-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 512.5 °C at 760 mmHg
• Flash Point: 263.8 °C
• Appearance: /
• Density: 1.134 g/cm³
• Vapor Pressure: 1.28E-10mmHg at 25°C
• Refractive Index: 1.471
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-(METHYLSULFONYLOXY)HEXANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-(METHYLSULFONYLOXY)HEXANOATE(878905-11-4)
• EPA Substance Registry System: TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-(METHYLSULFONYLOXY)HEXANOATE(878905-11-4)

Safety Data

• Hazardous Substances Data: 878905-11-4(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-(METHYLSULFONYLOXY)HEXANOATE, also known as Boc-lysine-MS, is a chemical compound used in the field of organic chemistry. It is a derivative of lysine, an essential amino acid, and is commonly used as a building block in peptide synthesis. TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-(METHYLSULFONYLOXY)HEXANOATE has a tert-butoxycarbonyl (Boc) protecting group on the amino group of lysine and a methylsulfonyloxy (Ms) protecting group on the carboxylic acid group of lysine. These protecting groups allow for selective manipulation of the lysine residue during peptide synthesis. TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-(METHYLSULFONYLOXY)HEXANOATE is known for its high purity and stability, making it a valuable reagent in the production of peptides for research and pharmaceutical purposes.

InChI:InChI=1/C16H31NO7S/c1-15(2,3)23-13(18)12(17-14(19)24-16(4,5)6)10-8-9-11-22-25(7,20)21/h12H,8-11H2,1-7H3,(H,17,19)

Upstream product

• 81323-62-8 (S)-tert-butyl 2-tert-butoxycarbonylamino-6-hydroxycarbonyl-1-hexanoate 
• 208520-00-7 (S)-2-tert-butoxycarbonylamino-6-diazo-5-oxohexanoic acid tert-butyl ester 
• 24277-39-2 N-tert-butoxycarbonyl glutamic acid tert-butyl ester 
• 124-63-0 methanesulfonyl chloride 
• 213176-15-9 (S)-(-)-tert-butyl-2-<(tert-butoxycarbonyl)amino>-6-hydroxyhexanoate 

Relevant articles and documents

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators

Inhibition of lysine-specific demethylase 1 (LSD1), a flavin-dependent histone demethylase, has recently emerged as a new strategy for treating cancer and other diseases. LSD1 interacts physically with SNAIL1, a member of the SNAIL/SCRATCH family of transcription factors. This study describes the discovery of SNAIL1 peptide-based inactivators of LSD1. We designed and prepared SNAIL1 peptides bearing a propargyl amine, hydrazine, or phenylcyclopropane moiety. Among them, peptide 3, bearing hydrazine, displayed the most potent LSD1-inhibitory activity in enzyme assays. Kinetic study and mass spectrometric analysis indicated that peptide 3 is a mechanism-based LSD1 inhibitor. Furthermore, peptides 37 and 38, which consist of cell-membrane-permeable oligoarginine conjugated with peptide 3, induced a dose-dependent increase of dimethylated Lys4 of histone H3 in HeLa cells, suggesting that they are likely to exhibit LSD1-inhibitory activity intracellularly. In addition, peptide 37 decreased the viability of HeLa cells. We believe this new approach for targeting LSD1 provides a basis for development of potent selective inhibitors and biological probes for LSD1.