87905-88-2Relevant articles and documents
Methoxymethylation of substituted alcohols using dimethoxymethane over Mo(VI)/ZrO2
Shyamsundar,Mohamed Shamshuddin,Ananda,Pratap
, p. 655 - 660 (2018/02/09)
The methoxymethylation reaction of alcohols was studied on Mo/ZrO2 (MZ) catalysts. The catalyst containing 5, 10 and 15 % Mo(VI) ions was prepared by solution combustion method. These solid acid catalytic materials were characterized by NH3- TPD, powder XRD, BET, FTIR spectroscopy, scanning electron microscopy, transmission electron spectroscopy and ICP- OES techniques. These catalysts were evaluated for their catalytic activity in the synthesis of methoxymethylation reactions of various substituted alcohols with dimethoxymethane in shorter reaction times (20 min) at moderate temperature (40 °C) with excellent yields (around 99 %). The main features of the Mo/ZrO2 catalyzed reaction are high yields, ease of scale up to gram scale, recyclable catalysts, inexpensive reagents, ecofriendly catalysts and a solvent free approach for the synthesis of methoxymethylated products.
INHIBITORS OF THE KYNURENINE PATHWAY
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, (2014/12/12)
The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and phannaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.
Synthesis and Properties of 2,2'-Bipyridin-3-ols and -3,3'-diols
Siemanowski, Werner,Witzel, Herbert
, p. 1731 - 1739 (2007/10/02)
The synthesis of the 2-furyl ketones 5-7 and 13 and their reaction with ammonium acetate in boiling acetic acid to 3-substituted 2,2'-bipyridines and to 2-(2-pyrimidinyl)-3-pyridinol (14) via a ring-transformation reaction are described.Strong intramolecular hydrogen bonds are responsible for their physical and chemical properties.
