879121-84-3Relevant articles and documents
Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
dos Santos, Paulo Victor P.,Ribeiro, Camila M.,Pavan, Fernando R.,Corbi, Pedro P.,Bergamini, Fernando R.G.,Carvalho, Marcos A.,D'Oliveria, Kaique A.,Cuin, Alexandre
, (2021/03/14)
In the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurem
Antimicrobial activities of synthetic arylidine nicotinic and isonicotinic hydrazones
Hayat, Muhammad,Khan, Khalid Mohammed,Saeed, Sumayya,Salar, Uzma,Khan, Momin,Baig, Taimoor,Ahmad, Aqeel,Parveen, Shahnaz,Taha, Muhammad
, p. 1057 - 1067 (2018/10/31)
Background: Despite availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. Identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. Methods: A library of synthetic arylidene nicotinic and isonicotinic hydrazones (1-63) were investigated for antimicrobial activities. Results: A number of derivatives showed significant to moderate antimicrobial activities against Gram positive and Gram negative bacterial cultures. Few compounds also showed antifungal activity against fungal cultures. Minimum Inhibitory Concentration (MIC) was calculated for the most active compounds 1, 7, 11, 19, 34, 46, 50, 51, and 55 against gram positive and gram negative cultures. Conclusion: Newly identified compounds may serve as lead for future research in order to get the more powerful antibacterial agents.
From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors
Soubhye, Jalal,Gelbcke, Michel,Van Antwerpen, Pierre,Dufrasne, Fran?ois,Boufadi, Mokhtaria Yasmina,Nève, Jean,Furtmüller, Paul G.,Obinger, Christian,Zouaoui Boudjeltia, Karim,Meyer, Franck
supporting information, p. 206 - 210 (2017/03/08)
The implementation of dynamic combinatorial libraries allowed the determination of highly active reversible and irreversible inhibitors of myeloperoxidase (MPO) at the nanomolar level. Docking experiments highlighted the interaction between the most activ
