87943-97-3

Basic information

• Product Name: ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE
• CAS NO: 87943-97-3
• Molecular Formula: C₁₁H₁₀Br₂O₃
• Molecular Weight: 0
• Mol File: 87943-97-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE(87943-97-3)
• EPA Substance Registry System: ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE(87943-97-3)

Safety Data

• Hazardous Substances Data: 87943-97-3(Hazardous Substances Data)

Usage

Description

ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE is a chemical compound with the molecular formula C11H10Br2O3. It is a brominated ester characterized by a bromo-substituted phenyl group attached to a ketone and an ester functional group. ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE is utilized as a building block in organic synthesis, particularly in the pharmaceutical and agrochemical industries for the production of various organic compounds.

Uses

Used in Pharmaceutical Industry:
ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE is used as a building block for the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE is used as a precursor for the production of agrochemicals, such as pesticides and herbicides, due to its reactive functional groups and potential for further chemical modification.
Used as an Intermediate in Chemical Synthesis:
ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE serves as an intermediate in the synthesis of other chemicals, contributing to the development of novel compounds with various applications.
Used in Research and Development:
ETHYL 2-BROMO-3-(4-BROMOPHENYL)-3-OXO-PROPANOATE is also utilized in research and development settings, where its unique properties can be explored for new applications and to enhance existing chemical processes.

Upstream product

• 99-90-1 para-bromoacetophenone 
• 26510-95-2 ethyl 4-Bromobenzoylacetate 

Downstream Products

• 87944-10-3 ethyl 4-(4-bromophenyl)-2-dimethylaminothiazole-5-carboxylate 
• 1007884-76-5 (2S)-2-(1-(4-bromophenyl)-3-ethoxy-1,3-dioxopropan-2-yl) 1-tert-butyl pyrrolidine-1,2-dicarboxylate 
• 1073467-90-9 3,6-bis(4-bromophenyl)-1H,4H-furo[3,4-c]furan-1,4-dione 
• 1423705-67-2 C₁₂H₁₀BrNO₃ 
• 834885-05-1 ethyl 2-amino-4-(4-bromophenyl)thiazole-5-carboxylate 
• 1423705-69-4 C₁₈H₁₅BrN₂O₃ 
• 1368558-04-6 C₁₀H₆BrNO₃ 
• 1423692-01-6 C₂₈H₂₃N₂O₄S^(1-)*Na⁽¹⁺⁾ 
• 1423685-40-8 C₂₈H₂₄N₂O₄S 

Relevant articles and documents

Highly efficient and green synthesis of 2,4-diphenyl substituted thiazoles

2,4-Diphenyl thiazole is an important organic intermediate and its derivatives contain multiple biological properties. In the present study, we reported a new protocol to synthesize 2,4-diphenyl thiazole analogs, which involved the bromination of ethyl benzoylacetates with NBS in the presence of 2-hydroxypropyl-β-cyclodextrin, followed by a direct cyclization with thiobenzamides in water. Compared with the reported method, the current protocol contains less reaction steps, milder reaction conditions, and simpler workup procedure.

Expanding Blaise-Type Reactions towards Indium-Mediated Transformations of α-Bromo-β-keto Esters with Nitriles

The aim of this work is the identification of mild reaction conditions for the Blaise-type transformation of brominated β-keto esters with nitriles to generate enamino-substituted keto esters. The best results were obtained when a combination of indium metal (0.7 equiv.) with indium trichloride (1.6 equiv.) were applied at 60 °C for 20 to 72 hours, and these conditions could be applied to a broad range of nitriles and a significant number of different β-keto esters. The transformation of aliphatic nitriles proved to be difficult and gave only moderate yields. However, aromatic nitriles gave good yields in many cases. The applicability range of β-keto esters is acceptable while some electron-deficient aryl-substituents on the keto ester were challenging substrates. Nevertheless, we were able to expand the scope of the Blaise-type reaction towards brominated β-keto esters significantly.

Preparation method for 2-halogenated-1,3-dicarbonyl derivative

The invention discloses a preparation method for a 2-halogenated-1,3-dicarbonyl derivative. The preparation method is suitable for wide 1,3-dicarbonyl derivatives. The raw materials are easy to obtain, and multiple varieties are achieved. The product obtained through the method is diversified in type, and can be directly used and used for other further reactions. According to the method, reaction conditions are gentle, the reaction operation and after-treatment process is simple, reaction time is short, the yield is high, pollution is low, and the preparation method is suitable for industrial production.