87980-97-0

Basic information

• Product Name: 1-Piperazineaceticacid,4-(2-aminoethyl)-(9CI)
• Synonyms: 1-Piperazineaceticacid,4-(2-aminoethyl)-(9CI);4-(2-AMINOETHYL)PIPERAZIN-1-YL]ACETIC ACID
• CAS NO: 87980-97-0
• Molecular Formula: C8H17N3O2
• Molecular Weight: 187.23948
• Product Categories: PIPERIDINE
• Mol File: 87980-97-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 350.0±32.0 °C(Predicted)
• Appearance: /
• Density: 1.155±0.06 g/cm3(Predicted)
• PKA: 4.24±0.10(Predicted)
• CAS DataBase Reference: 1-Piperazineaceticacid,4-(2-aminoethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazineaceticacid,4-(2-aminoethyl)-(9CI)(87980-97-0)
• EPA Substance Registry System: 1-Piperazineaceticacid,4-(2-aminoethyl)-(9CI)(87980-97-0)

Safety Data

• Hazardous Substances Data: 87980-97-0(Hazardous Substances Data)

Usage

Derivative of

Piperazine

Classification

Amino acid

Common uses

Synthesis of peptides, building block in organic chemistry

Potential applications

Pharmaceutical industry (medicinal chemistry), drug design and development

Versatility

Various potential uses in the pharmaceutical and chemical industries

Upstream product

• 127178-04-5 N-carboxymethyl-N'-(β-aminoethyl)piperazine trihydrochloride 
• 93968-73-1 2-(((2-(piperazin-1-yl)ethyl)imino)methyl)phenol 
• 127178-03-4 N-(β-carboxyethyl)-N'-(β-salicylideneaminoethyl)-piperazine 

Relevant articles and documents

NOVEL MULTIMERIC MOLECULES, A PROCESS FOR PREPARING THE SAME AND THE USE THEREOF FOR MANUFACTURING MEDICINAL DRUGS

The invention relates to a compound of the formula (I): in which k and j are independently 0 or 1, Y is a macrocycle in which the cycle includes 9 to 36 carbon atoms and is functionalised by three amino functions and by a chain for attaching the spacer arm Z via an X bond, Rc is a binding pattern with a receptor of the TNF superfamily, X is a chemical function for binding the Y group to the space arm, and Z is a bi-, tri- or tetra-functional spacer arm.

POLYBASIC AMINES. I. SYNTHESIS OF N-CARBOXYMETHYL- AND N-(β-CARBOXYETHYL)-N-(β-AMINOETHYL)PIPERAZINES

The hydrolysis of N-(β-cyanoethyl)-N'-(β-salicylideneaminomethyl)piperzine in the presence of hydrochloric acid leads to the formation of N-(β-carboxyethyl)-N'-(β-aminoethyl)piperazine, from which N-(β-carboxyethyl)-N'-(biscarboxymethyl-aminoethyl)piperazine is produced by the action of monochloroacetic acid.Under analogous conditions the hydrolysis of N-carboxymethyl-N'-(β-salicylideneaminoethyl)piperazine with concentrated hydrochloric acid followed by cyanoethylation of the product and hydrolysis gave N-carboxymethyl-N'-(di-β-carboxyethylaminoethyl)piperazine.