87981-04-2 Usage
General Description
N-Succinimidyl 11-(maleimido)undecanoate is a chemical compound commonly used in bioconjugation and protein labeling applications. It consists of a succinimide moiety that can react with primary amines on proteins to form stable amide bonds, and a maleimide group that selectively reacts with thiol groups on cysteine residues in proteins. N-Succinimidyl 11-(maleimido)undecanoate is often used to cross-link proteins or attach fluorophores, biotin, or other molecules to proteins for various biochemical and biophysical studies. Its long hydrophobic spacer arm of 11 carbons allows for increased flexibility and distance between the labeling site and the target protein, making it particularly useful for conjugating to larger proteins or complexes. Overall, N-Succinimidyl 11-(maleimido)undecanoate is a versatile and widely used reagent in chemical biology and biochemistry research.
Check Digit Verification of cas no
The CAS Registry Mumber 87981-04-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,9,8 and 1 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 87981-04:
(7*8)+(6*7)+(5*9)+(4*8)+(3*1)+(2*0)+(1*4)=182
182 % 10 = 2
So 87981-04-2 is a valid CAS Registry Number.
87981-04-2Relevant articles and documents
Synthesis N - maleic imide-based arylalkylic and its succinyl eater of method
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Paragraph 0079-0082, (2017/10/13)
The invention provides a method for synthesizing N-maleimidoalkyl acid and succinimido ester thereof, which comprises the following steps: (a) carrying out cyclization reaction on a compound disclosed as Formula (II) and phenyl 4-nitrotrifluoroacetate in an organic solvent in the presence of alkali to obtain N-maleimidoalkyl acid disclosed as Formula (III); and (b) reacting the N-maleimidoalkyl acid disclosed as Formula (III) and an acylation reagent in an organic solvent at reflux temperature to obtain an acyl chloride intermediate disclosed as (IV), reacting the acyl chloride intermediate disclosed as (IV) with N-hydroxy succinimide in an organic solvent in the presence of alkali to obtain the N-maleimidoalkyl acid succinimido ester disclosed as Formula (V). The method has the advantages of simple technique, high yield and high product purity, and is suitable for industrial production. The reaction route is disclosed in the specification.
