882033-92-3

Basic information

• Product Name: 3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester
• Synonyms: 3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester;tert-butyl 3-fluoro-4-Methylidenepiperidine-1-carboxylate;1-Boc-3-fluoro-4-Methylenepiperidine
• CAS NO: 882033-92-3
• Molecular Formula: C₁₁H₁₈FNO₂
• Molecular Weight: 215
• Mol File: 882033-92-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 261℃
• Flash Point: 111℃
• Appearance: /
• Density: 1.06
• Storage Temp.: 2-8°C
• PKA: -3.44±0.40(Predicted)
• CAS DataBase Reference: 3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester(882033-92-3)
• EPA Substance Registry System: 3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester(882033-92-3)

Safety Data

• Hazardous Substances Data: 882033-92-3(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester is a chemical compound with the molecular formula C11H18FNO2. It is primarily used as an intermediate in the synthesis of pharmaceutical products and agrochemicals. The tert-butyl ester group in the compound provides stability and protection for the carboxylic acid functionality, making it a valuable building block in organic synthesis. This chemical can be used in the production of various drugs and agricultural chemicals due to its versatile reactivity and potential for modification. Its unique structure and properties make it a valuable compound in the field of organic chemistry and drug development.

Upstream product

• 882033-91-2 3-fluoro-4-hydroxy-4-trimethylsilanylmethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 211108-50-8 tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate 

Downstream Products

• 882033-96-7 (+/-)-trans-tert-butyl 1-{3-fluoro-4-[(methylsulfonyl)oxymethyl]piperidin-1-yl}carboxylate 
• 882033-96-7 tert-butyl 3-fluoro-4-{[(methylsulfonyl)oxy]methyl}piperidine-1-carboxylate 
• 1303973-77-4 tert-butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 
• 1303972-96-4 C₁₁H₂₁FN₂O₂ 
• 1303972-96-4 C₁₁H₂₁FN₂O₂ 
• 882033-96-7 (+/-)-cis-tert-butyl 1-{3-fluoro-4-[(methylsulfonyl)oxymethyl]piperidin-1-yl}carboxylate 

Relevant articles and documents

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Synthesis and in vitro characterization of trans- and cis-[ 18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3- fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor

Diastereoisomeric compounds [18F]cis- and [18F]trans- 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoro-piperidine-1- carboxylates were successfully synthesized as new subtype-selective PET radiotracers for imaging the NR2B sub

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