882562-43-8

Basic information

• Product Name: 3-(6-fluoro-1H-indol-3-yl)-3-oxopropanenitrile
• Synonyms: 3-(6-fluoro-1H-indol-3-yl)-3-oxopropanenitrile
• CAS NO: 882562-43-8
• Molecular Formula: C₁₁H₇FN₂O
• Molecular Weight: 202.1844832
• Mol File: 882562-43-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(6-fluoro-1H-indol-3-yl)-3-oxopropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(6-fluoro-1H-indol-3-yl)-3-oxopropanenitrile(882562-43-8)
• EPA Substance Registry System: 3-(6-fluoro-1H-indol-3-yl)-3-oxopropanenitrile(882562-43-8)

Safety Data

• Hazardous Substances Data: 882562-43-8(Hazardous Substances Data)

Upstream product

• 23077-44-3 6-fluoroindole-3-carboxylic acid 
• 75-05-8 acetonitrile 
• 399-51-9 6-fluoro-1H-indole 
• 372-09-8 cyanoacetic acid 

Relevant articles and documents

Rh(iii)-Catalyzed dual C-H functionalization of 3-(1: H -indol-3-yl)-3-oxopropanenitriles with sulfoxonium ylides or diazo compounds toward polysubstituted carbazoles

A rhodium-catalyzed annulation of 3-(1H-indol-3-yl)-3-oxopropanenitriles with sulfoxonium ylides or diazo compounds has been developed, leading to a series of polysubstituted carbazoles in moderate to good yields. This procedure proceeded with formal Rh(iii)-catalyzed (4 + 2) cycloaddition, with the functionalization of 2-C-H bonds of indole in a step-economical procedure. Additionally, this reaction could also be conducted under acidic conditions when diazo compounds were employed as the reaction partners, which was a complement to the annulation of sulfoxonium ylides under weak basic conditions.