882847-13-4 Usage
Description
BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID, also known as t-Boc-N-amido-PEG6-acid, is a PEGylated compound featuring a terminal carboxylic acid and a Boc-protected amino group. The hydrophilic PEG (polyethylene glycol) spacer enhances its solubility in aqueous environments, while the terminal carboxylic acid allows for the formation of stable amide bonds with primary amine groups through activation by coupling agents like EDC or HATU. The Boc group can be removed under mild acidic conditions to reveal the free amine, making this molecule versatile for various applications in chemical and pharmaceutical synthesis.
Uses
Used in Chemical Synthesis:
BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID is used as a building block for the synthesis of complex molecules, taking advantage of its reactive carboxylic acid and protected amine group. The PEG spacer provides increased solubility and stability to the resulting compounds.
Used in Pharmaceutical Development:
In the pharmaceutical industry, BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID is used as a key intermediate in the development of drug candidates. The Boc-protected amine allows for selective deprotection and subsequent reactions, while the PEG spacer can improve the pharmacokinetic properties of the final drug, such as solubility, stability, and bioavailability.
Used in Drug Delivery Systems:
BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID is utilized in the design of drug delivery systems, where the PEG spacer can enhance the solubility and circulation time of drug carriers, and the terminal carboxylic acid can be used to attach drug molecules or targeting ligands through amide bond formation.
Used in Bioconjugation:
In the field of bioconjugation, BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID serves as a versatile linker to connect biologically active molecules, such as peptides, proteins, or nucleic acids, with other molecules or surfaces. The PEG spacer can reduce immunogenicity and non-specific interactions, while the terminal carboxylic acid and Boc-protected amine provide reactive sites for conjugation.
Check Digit Verification of cas no
The CAS Registry Mumber 882847-13-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,2,8,4 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 882847-13:
(8*8)+(7*8)+(6*2)+(5*8)+(4*4)+(3*7)+(2*1)+(1*3)=214
214 % 10 = 4
So 882847-13-4 is a valid CAS Registry Number.
882847-13-4Relevant articles and documents
Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof
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Page/Page column 207; 208; 211, (2019/11/11)
Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.
