882847-32-7

Basic information

• Product Name: FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID
• Synonyms: FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID;FMoc-NH-PEG5-CH2CH2COOH;5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid 1-(9H-fluoren-9-ylmethyl) ester;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid;Fmoc-N-amido-PEG5-acid;Fmoc-PEG5-CH2CH2COOH;Fmoc-PEG5-propionic acid;Fmoc-NH-PEG5-COOH
• CAS NO: 882847-32-7
• Molecular Formula: C₂₈H₃₇NO₉
• Molecular Weight: 531.59
• Product Categories: amino acid
• Mol File: 882847-32-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 711.4±60.0 °C(Predicted)
• Appearance: /
• Density: 1.210±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID(882847-32-7)
• EPA Substance Registry System: FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID(882847-32-7)

Safety Data

• Hazardous Substances Data: 882847-32-7(Hazardous Substances Data)

Usage

Description

FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID is a PEGylated compound containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG chain increases solubility in aqueous media, and the Fmoc group can be deprotected under basic conditions to obtain the free amine for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators to form a stable amide bond.

Uses

Used in Pharmaceutical Industry:
FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID is used as a PEG linker for improving the solubility and stability of therapeutic agents. The Fmoc-protected amine allows for selective deprotection and conjugation to various drug molecules, enhancing their pharmacokinetic properties and reducing immunogenicity.
Used in Bioconjugation:
FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID is used as a bioconjugation agent for attaching biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The terminal carboxylic acid can form stable amide bonds with primary amine groups, enabling the creation of various conjugates for research and therapeutic applications.
Used in Drug Delivery Systems:
FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID is used as a component in drug delivery systems to improve the solubility, stability, and targeted delivery of therapeutic agents. The PEG chain can reduce the immunogenicity and non-specific interactions of the drug, while the Fmoc-protected amine allows for selective conjugation to drug molecules or carriers for controlled release and targeted delivery.