88288-12-4

Basic information

• Product Name: N-Acetyl 5-bromo-2-fluoroaniline
• Synonyms: N-Acetyl 5-bromo-2-fluoroaniline;2-acetamido-4-bromo-1-fluorobenzene;N-(5-Bromo-2-fluorophenyl)acetamide;5'-Bromo-2'-fluoroacetanilide98%;N-(5-Bromo-2-fluorophenyl)
• CAS NO: 88288-12-4
• Molecular Formula: C₈H₇BrFNO
• Molecular Weight: 232
• Mol File: 88288-12-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 328.2°C at 760 mmHg
• Flash Point: 152.3°C
• Appearance: /
• Density: 1.623g/cm³
• Vapor Pressure: 0.000193mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: N-Acetyl 5-bromo-2-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl 5-bromo-2-fluoroaniline(88288-12-4)
• EPA Substance Registry System: N-Acetyl 5-bromo-2-fluoroaniline(88288-12-4)

Safety Data

• Hazardous Substances Data: 88288-12-4(Hazardous Substances Data)

Usage

General Description

N-Acetyl 5-bromo-2-fluoroaniline is a chemical compound used in the production of pharmaceuticals, dyes, and agrochemicals. It is an N-acetylated derivative of 5-bromo-2-fluoroaniline, which makes it more stable and suitable for various applications. N-Acetyl 5-bromo-2-fluoroaniline has a bromine atom and a fluorine atom attached to an aniline ring, giving it unique properties that make it useful in organic synthesis. N-Acetyl 5-bromo-2-fluoroaniline is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, making it a valuable chemical in the field of organic chemistry and industrial manufacturing.

InChI:InChI=1/C8H7BrFNO/c1-5(12)11-8-4-6(9)2-3-7(8)10/h2-4H,1H3,(H,11,12)

Upstream product

• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 7439-89-6 iron 
• 2924-09-6 5-bromo-2-fluoroaniline 
• 108-24-7 acetic anhydride 
• 621-38-5 3-bromoacetanilide 

Downstream Products

• 874959-51-0 N-[5-(cis-3,5-dimethyl-1-piperazinyl)-2-fluorophenyl]acetamide 

Relevant articles and documents

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PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS

The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Re, Rf and Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors . Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.

A Novel Electrophilic Fluorination of Activated Aromatic Rings Using Acetyl Hypofluorite, Suitable also for Introducing (18)F into Benzene Nuclei

Acetyl hypofluorite (1) is a new compound that serves as a novel electrophilic fluorinating agent.It is special in the sense that, while it is very reactive, it is still a milder reagent than other fluoroxy compounds such as CF3OF or CF3COOF.It is synthesized directly from elemental fluorine and is used without any isolation or purification.The hypofluorite 1 reacts efficiently and selectively with activated aromatic rings,particularly phenol and aniline derivatives after suitable protection of the hydroxyl and the amino groups.The net result of the reaction is partly according to classical aromatic electrophilic substitution.Unlike such a substitution, however, the electrophilic fluorine atom of 1 substitutes mainly an ortho hydrogen and only occasionally small amounts of p-fluoro derivatives are found.Evidence supports the mechanism for this aromatic fluorination as being mainly an addition-elimination one.In many cases the electrophilic aromatic fluorinations can replace the classical 60-year-old Balz-Schiemann method, which until today is probably the most used procedure.Since aromatic fluorination with 1 is a very fast reaction and since 1 is produced directly from elemental fluorine, this is probably one of the best ways for introduction of the short-living radioisotope (18)F into activated aromatic rings.This will greatly encourage the synthesis of compounds suitable for use in the rapidly developing field of positron emitting transaxial tomography, which in itself depends on the efficient and easy supply of compounds possessing positron emitting isotopes.