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883028-82-8

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883028-82-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 883028-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,3,0,2 and 8 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 883028-82:
(8*8)+(7*8)+(6*3)+(5*0)+(4*2)+(3*8)+(2*8)+(1*2)=188
188 % 10 = 8
So 883028-82-8 is a valid CAS Registry Number.

883028-82-8Downstream Products

883028-82-8Relevant articles and documents

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Molina, Jennifer R.,Sun, Yuting,Protopopova, Marina,Gera, Sonal,Bandi, Madhavi,Bristow, Christopher,McAfoos, Timothy,Morlacchi, Pietro,Ackroyd, Jeffrey,Agip, Ahmed-Noor A.,Al-Atrash, Gheath,Asara, John,Bardenhagen, Jennifer,Carrillo, Caroline C.,Carroll, Christopher,Chang, Edward,Ciurea, Stefan,Cross, Jason B.,Czako, Barbara,Deem, Angela,Daver, Naval,De Groot, John Frederick,Dong, Jian-Wen,Feng, Ningping,Gao, Guang,Gay, Jason,Do, Mary Geck,Greer, Jennifer,Giuliani, Virginia,Han, Jing,Han, Lina,Henry, Verlene K.,Hirst, Judy,Huang, Sha,Jiang, Yongying,Kang, Zhijun,Khor, Tin,Konoplev, Sergej,Lin, Yu-Hsi,Liu, Gang,Lodi, Alessia,Lofton, Timothy,Ma, Helen,Mahendra, Mikhila,Matre, Polina,Mullinax, Robert,Peoples, Michael,Petrocchi, Alessia,Rodriguez-Canale, Jaime,Serreli, Riccardo,Shi, Thomas,Smith, Melinda,Tabe, Yoko,Theroff, Jay,Tiziani, Stefano,Xu, Quanyun,Zhang, Qi,Muller, Florian,Depinho, Ronald A.,Toniatti, Carlo,Draetta, Giulio F.,Heffernan, Timothy P.,Konopleva, Marina,Jones, Philip,Di Francesco, M. Emilia,Marszalek, Joseph R.

, p. 1036 - 1046 (2018/06/15)

Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosphorylation (OXPHOS) has remained largely unexplored, partly owing to an incomplete understanding of tumor contexts in which OXPHOS is essential. Here, we report the discovery of IACS-010759, a clinical-grade small-molecule inhibitor of complex I of the mitochondrial electron transport chain. Treatment with IACS-010759 robustly inhibited proliferation and induced apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis. In models of brain cancer and AML, tumor growth was potently inhibited in vivo following IACS-010759 treatment at well-tolerated doses. IACS-010759 is currently being evaluated in phase 1 clinical trials in relapsed/refractory AML and solid tumors.

HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE

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Paragraph 0237; 0238B, (2014/03/25)

The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

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