883555-07-5

Basic information

• Product Name: TERT-BUTYL (1-ETHYLPYRROLIDIN-2-YL)METHYLCARBAMATE
• Synonyms: TERT-BUTYL (1-ETHYLPYRROLIDIN-2-YL)METHYLCARBAMATE
• CAS NO: 883555-07-5
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.33
• Mol File: 883555-07-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL (1-ETHYLPYRROLIDIN-2-YL)METHYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL (1-ETHYLPYRROLIDIN-2-YL)METHYLCARBAMATE(883555-07-5)
• EPA Substance Registry System: TERT-BUTYL (1-ETHYLPYRROLIDIN-2-YL)METHYLCARBAMATE(883555-07-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 883555-07-5(Hazardous Substances Data)

Usage

Description

TERT-BUTYL (1-ETHYLPYRROLIDIN-2-YL)METHYLCARBAMATE, also known as N-[[(2S)-1-Ethyl-2-pyrrolidinyl]methyl]carbamic Acid 1,1-Dimethylethyl Ester, is a chemical compound that serves as a crucial building block in the synthesis of Amisulpride (A633250) related compounds.

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL (1-ETHYLPYRROLIDIN-2-YL)METHYLCARBAMATE is used as a key intermediate in the synthesis of Amisulpride (A633250) related compounds for the development of pharmaceuticals targeting various therapeutic applications. Its role in the synthesis process is essential for creating effective and innovative treatments in the medical field.

Upstream product

• 26116-12-1 1-ethyl-2-pyrrolidinemethanamine 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Synthesis method of process impurity of amisulpride

The invention discloses a synthesis method of a process impurity of amisulpride, and belongs to the technical field of chemical pharmacy. N-ethyl-2-aminomethylpyrrolidine (2) reacts with (BOC)2O to obtain 1-ethyl pyrrolidine-2-methyl tert-butyl carbamate (3); CH3I is added under the alkaline condition of NaH, and methylation is performed to obtain N-(1-ethyl pyrrolidine-2-methyl), N-methyl tert-Butyl carbamate (4); under an acidic condition, hydrolysis is carried out to obtain N-ethyl-2-methylaminomethylpyrrolidine (5); and finally reaction with 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid (6) is performed under the catalysis of theorganic alkali N',N-carbonyldiimidazole (CDI) to obtain an amisulpride impurity (1). The synthesized high-purity amisulpride impurity is used as an impurity standard substance in detection and analysis ofamisulpride finished products, so that the positioning accuracy of the amisulpride impurity is improved; control on impurities is enhanced, and the purpose of controlling the quality of the finished amisulpride is finally achieved; and the raw materials are simple and easy to obtain, and operation is simple.