88393-07-1

Basic information

• Product Name: METHYL 4-[(PHENYLTHIO)METHYL]BENZOATE
• Synonyms: METHYL 4-[(PHENYLTHIO)METHYL]BENZOATE
• CAS NO: 88393-07-1
• Molecular Formula: C₁₅H₁₄O₂S
• Molecular Weight: 258.34
• Mol File: 88393-07-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 394.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• CAS DataBase Reference: METHYL 4-[(PHENYLTHIO)METHYL]BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-[(PHENYLTHIO)METHYL]BENZOATE(88393-07-1)
• EPA Substance Registry System: METHYL 4-[(PHENYLTHIO)METHYL]BENZOATE(88393-07-1)

Safety Data

• Hazardous Substances Data: 88393-07-1(Hazardous Substances Data)

Upstream product

• 6232-88-8 4-bromomethylbenzoic Acid 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 108-98-5 thiophenol 
• 1642-81-5 p-(chloromethyl)benzoic acid 
• 34040-64-7 p-methyloxycarbonylbenzyl chloride 
• 88382-49-4 4-<(Phenylthio)methyl>benzoic acid 
• 149-73-5 trimethyl orthoformate 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 

Downstream Products

• 59584-27-9 Methyl 4-<(phenylsulfonyl)methyl>benzoate 
• 139-66-2 diphenyl sulfide 
• 88393-10-6 methyl 4-amino-4-deoxy-10-(phenylsulfonyl)-8,10-dideazapteroate 
• 88393-08-2 α-methyl-p-carbomethoxybenzyl phenyl sulfoxide 
• 1076-96-6 methyl 4-vinylbenzoate 
• 880348-63-0 4-(1-phenylsulfanyl-vinyl)-benzoic Acid Methyl Ester 
• 856251-46-2 4-benzenesulfinylmethylbenzoic acid methyl ester 

Relevant articles and documents

Photoredox/Nickel Dual Catalytic Cross-Coupling of Potassium Thiomethyltrifluoroborates with Aryl and Heteroaryl Bromides

The cross-coupling of S-aryl and S-alkyl potassium thiomethyltrifluoroborates with aryl and heteroaryl bromides is reported via photoredox/nickel dual catalysis. The transformation is achieved under mild conditions with commercially available or readily prepared, air stable reagents and affords benzylthioether products in moderate to good yields with good functional group tolerance. A practical and improved synthesis of potassium thiomethyltrifluoroborates is also reported that affords access to previously undescribed reagents.

Neutral sulfur nucleophiles: Synthesis of thioethers and thioesters by substitution reactions of N-heterocyclic carbene boryl sulfides and thioamides

Newly discovered boryl sulfides and N-borylthioamides are shown to serve as neutral sources of sulfur nucleophiles in substitutions reactions. For example, heating of diMe-Imd-BH(SPh)2 with benzyl bromides, primary bromides, or acid chlorides provides the corresponding thioethers or thioesters in high yields. Likewise, N-phenyltetrazole thioethers/esters are made from a readily available N-borylthionotetrazole. The formation of the boryl sulfide and its onward nucleophilic substitution can be telescoped down to a one-pot reaction whose components are an NHC-borane (NHC-BH3), a disulfide, and an electrophile.

α,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS

Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents based on their histone deacetylase inhibitory activity.