88398-81-6

Basic information

• Product Name: 1-Methyl-4-ethylformate-5-pyrazole sulfonamide
• Synonyms: 4-Ethyl-1H-pyrazole-5-sulfonaMide acetate;4-ethyl-1H-pyrazole-5-sulfonamide, acetate salt;5-(AMINOSULFONYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;1-METHYL-4-ETHYL FORMATE-5-PYRAZOLE SULFONAMIDE;ETHYL 1-METHYL-5-SULFAMOYL-PYRAZOLE-4-CARBOXYLATE;1-methyl-4-ethylformate-5-pyrazole sulphonamide;1-Methyl-4-ethy1 formate-5-pyrazole sulfonamide
• CAS NO: 88398-81-6
• Molecular Formula: C₇H₁₁N₃O₄S
• Molecular Weight: 234.25
• Mol File: 88398-81-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 449.504 °C at 760 mmHg
• Flash Point: 225.652 °C
• Appearance: /
• Density: 1.54
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.614
• PKA: 9.52±0.60(Predicted)
• CAS DataBase Reference: 1-Methyl-4-ethylformate-5-pyrazole sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-ethylformate-5-pyrazole sulfonamide(88398-81-6)
• EPA Substance Registry System: 1-Methyl-4-ethylformate-5-pyrazole sulfonamide(88398-81-6)

Safety Data

• Hazardous Substances Data: 88398-81-6(Hazardous Substances Data)

Usage

General Description

1-Methyl-4-ethylformate-5-pyrazole sulfonamide is a chemical compound that belongs to the class of sulfa drugs. It is a sulfonamide derivative that has been found to exhibit potent antibacterial and antifungal properties. 1-Methyl-4-ethylformate-5-pyrazole sulfonamide has shown potential in the treatment of various bacterial and fungal infections, including those caused by resistant strains. It works by inhibiting the growth of microorganisms through the interference with folate synthesis. Additionally, 1-Methyl-4-ethylformate-5-pyrazole sulfonamide has also been studied for its potential in inhibiting the growth of cancer cells, making it a compound of interest for potential anticancer therapies.

InChI:InChI=1/C7H11N3O4S/c1-3-14-7(11)5-4-9-10(2)6(5)15(8,12)13/h4H,3H2,1-2H3,(H2,8,12,13)

Upstream product

• 93697-74-6 pyrazolsulfuron-ethyl 
• 88398-78-1 1-methyl-5-hydroxypyrazol-4-carboxylic acid ethyl ester 
• 85290-80-8 ethyl 1-methylpyrazole-4-carboxylate 
• 88398-82-7 ethyl 5-(chlorosulfonyl)-1-methyl-1H-pyrazole-4-carboxylate 

Downstream Products

• 139093-37-1 C₉H₁₃N₃O₆S 

Relevant articles and documents

Synthesis method of pyrazosulfuron-ethyl intermediate 4-ethoxycarbonyl-5-sulfamine-1-methylpyrazole

The invention discloses a synthesis method of a pyrazosulfuron-ethyl intermediate 4-ethoxycarbonyl-5-sulfamine-1-methylpyrazole. The method comprises the following steps: (1) performing condensation reaction on 4-ethoxycarbonyl-5-hydroxyl-1-methylpyrazole and dimethylthiocarbamoyl chloride to obtain 4-ethoxycarbonyl-5-dimethylthio carbamoyl oxy-1-methylpyrazole; (2) performing transposition rearrangement reaction on the 4-ethoxycarbonyl-5-dimethylthio carbamoyl oxy-1-methylpyrazole to obtain 4-ethoxycarbonyl-5-dimethyl carbamoyl sulfenyl-1-methylpyrazole; (3) performing chlorosulfonation reaction on the 4-ethoxycarbonyl-5-dimethyl carbamoyl sulfenyl-1-methylpyrazole and chlorine to obtain 4-ethoxycarbonyl-5-sulfonyl chloride-1-methylpyrazole; (4) performing ammoniation reaction on the 4-ethoxycarbonyl-5-sulfonyl chloride-1-methylpyrazole and ammonium hydroxide to obtain the 4-ethoxycarbonyl-5-sulfamine-1-methylpyrazole. The method is less in environment pollution, particularly high in product purity, and high in total yield.

Sulfonylureas as dual acting agents - Synthesis and biological activity

2-Amino-5-aryl/alkyl-1,3,4-thiadiazoles 3a-e were used as intermediates in the synthesis of some 1,3-substituted urea derivatives 5a-o to evaluate their antidiabetic activity as well as antibacterial activity. The obtained compounds exhibited marginal activity against the animal models and the selected microorganisms.