884625-45-0Relevant articles and documents
A convenient synthesis and cytotoxic activity of 3-aryl-5-pentyl-1,2,4- oxadiazoles from carboxylic acid esters and arylamidoximes under solvent-free conditions
Barros, Carlos Jonnatan Pimentel,De Souza, Zilyane Cardoso,De Freitas, Jucleiton José Rufino,Silva, Paulo Bruno Norberto Da,Milit?o, Gardenia Carmen Gadelha,Silva, Teresinha Gon?alves Da,Freitas, Juliano Carlo Rufino,De Freitas Filho, Jo?o Rufino
, p. 2359 - 2362 (2014)
The synthesis of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes in the presence of potassium carbonate is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in good yields. The structures of the synthesized compounds were elucidated using IR, 1H and 13C NMR spectroscopy and elemental analysis and their antiproliferative activities was evaluated against three different human cell lines.
