885271-72-7

Basic information

• Product Name: 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
• Synonyms: 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE;6-BROMO-1H-INDAZOLE-3-CARBOXALDEHYDE;6-BROMO-INDAZOLE-3-CARBOXALDEHYDE;Bromoindazolecarboxaldehyde;1H-Indazole-3-carboxaldehyde,6-broMo-;1-(6-bromo-1H-indazol-3-yl)-N,N-dimethylmethanamine
• CAS NO: 885271-72-7
• Molecular Formula: C₈H₅BrN₂O
• Molecular Weight: 225.04
• Product Categories: Indazole
• Mol File: 885271-72-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 414.1 °C at 760 mmHg
• Flash Point: 204.2 °C
• Appearance: /
• Density: 1.83 g/cm³
• Vapor Pressure: 4.58E-07mmHg at 25°C
• Refractive Index: 1.769
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.82±0.40(Predicted)
• CAS DataBase Reference: 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE(885271-72-7)
• EPA Substance Registry System: 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE(885271-72-7)

Safety Data

• Hazardous Substances Data: 885271-72-7(Hazardous Substances Data)

Usage

General Description

6-Bromo-1H-indazole-3-carbaldehyde is a chemical compound with the molecular formula C9H6BrN2O. It is a yellow crystalline powder commonly used as an intermediate in the synthesis of various pharmaceutical and agrochemical compounds. Its heterocyclic structure makes it valuable in the production of pharmaceuticals, especially in the development of new drugs targeting various diseases. 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE has also been studied for its potential antimicrobial and antiviral properties. Additionally, it is used in organic synthesis as a building block for the creation of diverse chemical compounds due to its versatility and reactivity.

InChI:InChI=1/C8H5BrN2O/c9-5-1-2-6-7(3-5)10-11-8(6)4-12/h1-4H,(H,10,11)

Upstream product

• 60956-26-5 4-bromo-2-nitrotoluene 
• 52415-29-9 6-bromo-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 
• 67-64-1 acetone 

Downstream Products

• 1021859-29-9 6-bromo-1-methyl-1H-indazole-3-carboxylic acid 

Relevant articles and documents

JAK inhibitor compound and application thereof

The invention relates to a JAK inhibitor compound and application thereof. Specifically, the invention discloses a compound shown as a formula (G), or an isotope labeled compound, or an optical isomer, a geometrical isomer, a tautomer or an isomer mixture of the compound, or a pharmaceutically acceptable salt of the compound, or a prodrug of the compound, or a metabolite of the compound. The invention also relates to the medical application of the compound.

3-formyl-1H-substituted indazole and preparation method thereof

The embodiment of the invention discloses 3-formyl-1H-substituted indazole and a preparation method thereof. The method comprises the step of taking 2-nitro-substituted toluene as a raw material to prepare a compound in a formula (VI). The method takes the 2-nitro-substituted toluene as the raw material to prepare the 3-formyl-1H-substituted indazole. The raw material used by the preparation method is cheap and easy to get; a product with relatively high purity can be obtained without column chromatography separation and purification; the method can be well applied to practical production andapplication. Further, reaction conditions required by a whole preparation process are mild; the use of reagents with strong reducibility or strong oxidability is not involved; the method is suitable for industrial production.

JAK KINASE INHIBITOR COMPOUNDS FOR TREATMENT OF RESPIRATORY DISEASE

The invention provides compounds of formula (I): wherein X is (I) and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.