885278-42-2

Basic information

• Product Name: METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE
• Synonyms: METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE;6-bromo-1H-indazole-3-carboxylic acid methyl ester;6-Bromo-3-(methoxycarbonyl)-1H-indazole;1H-Indazole-3-carboxylic acid, 6-broMo-, Methyl ester
• CAS NO: 885278-42-2
• Molecular Formula: C₉H₇BrN₂O₂
• Molecular Weight: 255.07
• Mol File: 885278-42-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 399.674 °C at 760 mmHg
• Flash Point: 195.516 °C
• Appearance: /
• Density: 1.71 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.676
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.71±0.40(Predicted)
• CAS DataBase Reference: METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE(885278-42-2)
• EPA Substance Registry System: METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE(885278-42-2)

Safety Data

• Hazardous Substances Data: 885278-42-2(Hazardous Substances Data)

Usage

General Description

Methyl 6-Bromo-1H-indazole-3-carboxylate is a chemical compound with the molecular formula C9H7BrN2O2. It is used in organic synthesis as a building block for producing various pharmaceuticals, agrochemicals, and other fine chemicals. The compound is known for its potential biological activities and is also used in the development of new drug candidates. Its unique structure and properties make it an important intermediate in the pharmaceutical and chemical industries, with potential applications in drug discovery and development. However, it is essential to handle and use this compound with caution due to its potential hazards.

InChI:InChI=1/C9H7BrN2O2/c1-14-9(13)8-6-3-2-5(10)4-7(6)11-12-8/h2-4H,1H3,(H,11,12)

Upstream product

• 660823-36-9 6-bromo-1H-indazole-3-carboxylic acid 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 67-56-1 methanol 
• 6326-79-0 6-bromoisatin 

Downstream Products

• 1268245-23-3 6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid 
• 660823-36-9 6-bromo-1H-indazole-3-carboxylic acid 
• 946427-77-6 6-bromo-1-methyl-1H-indazole-3-carboxylic acid methyl ester 

Relevant articles and documents

Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities

Aberrant activation of p21-activated kinase 1 (PAK1) is associated with tumour progression, and PAK1 has been recognized as a promising target for anticancer drug discovery. However, the development of potent PAK1 inhibitors with satisfactory kinase selec

6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR

The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.

NOVEL FXR (NR1H4 ) BINDING AND ACTIVITY MODULATING COMPOUNDS

The present invention relates to compounds which bind to the NR1 H4 receptor (FXR) and act as agonists of the NR1 H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.