885280-38-6

Basic information

• Product Name: (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: TERT-BUTYL 3-OXOCYCLOHEXYLCARBAMATE;(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER;3-N-BOC-AMINO CYCLOHEXANONE;tert-butyl N-(3-oxocyclohexyl)carbaMate;3-(Boc-aMino)cyclohexanone;(3-Oxo-cyclohexyl)-carbaMic acid benzyl ester;3-Aminocyclohexan-1-one, N-BOC protected;tert-Butyl (3-oxocyclohexyl)carbamate, 1-[(tert-Butoxycarbonyl)amino]-3-oxocyclohexane
• CAS NO: 885280-38-6
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.27
• Mol File: 885280-38-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 335.9 °C at 760 mmHg
• Flash Point: 157 °C
• Appearance: /Solid
• Density: 1.06 g/cm³
• Refractive Index: 1.474
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 12.01±0.20(Predicted)
• CAS DataBase Reference: (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER(885280-38-6)
• EPA Substance Registry System: (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER(885280-38-6)

Safety Data

• Hazardous Substances Data: 885280-38-6(Hazardous Substances Data)

Usage

Uses

(3-Oxocyclohexyl)carbamic Acid tert-Butyl Ester is used to prepare (benzyloxy)benzamides as TRPM8 antagonists.

InChI:InChI=1/C11H19NO3/c1-11(2,3)15-10(14)12-8-5-4-6-9(13)7-8/h8H,4-7H2,1-3H3,(H,12,14)

Upstream product

• 930-68-7 cyclohexenone 
• 4248-19-5 tert-butyl carbazate 
• 3712-40-1 tert-butyl cyclohexylcarbamate 
• 610302-03-9 tert-butyl N-(3-hydroxycyclohexyl)carbamate 
• 6850-39-1 3-aminocyclohexanol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1119283-52-1 methyl-[3-(4-methylpiperazin-1-yl)cyclohexyl]amine 
• 1119282-90-4 2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide 
• 1119282-87-9 2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1R,3S)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide 
• 1529782-19-1 tert-butyl 3-hydroxy-3-methylcyclohexylcarbamate 

Relevant articles and documents

Divergent Stereoselectivity in Phosphothreonine (pThr)-Catalyzed Reductive Aminations of 3-Amidocyclohexanones

Phosphothreonine (pThr)-embedded peptide catalysts are found to mediate the reductive amination of 3-amidocyclohexanones with divergent selectivity. The choice of peptide sequence can be used to alter the diastereoselectivity to favor either the cis-product or trans-product, which are obtained in up to 93:7 er. NMR studies and DFT calculations are reported and indicate that both pathways rely on secondary interactions between substrate and catalyst to achieve selectivity. Furthermore, catalysts appear to accomplish a parallel kinetic resolution of the substrates. The facility for phosphopeptides to tune reactivity and access multiple products in reductive aminations may translate to the diversification of complex substrates, such as natural products, at numerous reactive sites.

SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

An unexpected oxidation of unactivated methylene C-H using DIB/TBHP protocol

An in situ generated hypervalent iodine species, bis(tert-butylperoxy) iodobenzene, was used as a peroxy radical source for the oxidation of unreactive, remote, and isolated alkyl (cyclic or aliphatic) esters and amides to the corresponding keto compounds under very mild conditions.