885519-56-2

Basic information

• Product Name: 1H-Indazole,6-chloro-4-iodo-
• Synonyms: 1H-Indazole,6-chloro-4-iodo-
• CAS NO: 885519-56-2
• Molecular Formula: C₇H₄ClIN₂
• Molecular Weight: 278.47753
• Mol File: 885519-56-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 388.2±22.0 °C(Predicted)
• Appearance: /
• Density: 2.156
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11.78±0.40(Predicted)
• CAS DataBase Reference: 1H-Indazole,6-chloro-4-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole,6-chloro-4-iodo-(885519-56-2)
• EPA Substance Registry System: 1H-Indazole,6-chloro-4-iodo-(885519-56-2)

Safety Data

• Hazardous Substances Data: 885519-56-2(Hazardous Substances Data)

Usage

General Description

"1H-Indazole,6-chloro-4-iodo-" is a specific type of chemical compound that belongs to the indazole class, characterized by a bicyclic structure which includes two nitrogen atoms in the five-membered ring. The notation "1H" indicates the presence of a hydrogen atom, while the "6-chloro-4-iodo" denomination suggests that a chlorine atom is attached at position 6 and an iodine atom at position 4 in the indazole ring structure. It's often used in the field of pharmaceutical research and in the synthesis of various organic compounds. The exact properties of this chemical can drastically vary depending on its specific formulation and it is involved in sophisticated chemical reactions requiring experienced handling.

Upstream product

• 35572-79-3 5-chloro-2-methyl-1,3-dinitro-benzene 

Downstream Products

• 1254036-90-2 {2-[6-{1-[(1,1-dimethylethyl)(dimethyl)silyl]-1H-indol-4-yl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazol-5-yl}methanol 
• 1254036-82-2 methyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 1254036-81-1 ethyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 1364799-92-7 C₇H₈O₃S*C₂₆H₂₈N₆O 
• 1364802-72-1 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1254036-86-6 6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1361970-37-7 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt 
• 1361970-34-4 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt 
• 1361970-55-9 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide 
• 1254036-80-0 6-chloro-1-(phenylsulfonyl)-4-(trimethylstannanyl)-1H-indazole 
• 1254036-85-5 6-chloro-4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1254036-84-4 4-[5-(bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole 

Relevant articles and documents

Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib

This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in a pilot plant on a multikilogram scale to deliver >100 kg of product.