885963-71-3Relevant articles and documents
Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB2) ligand designed for PET studies
Heimann, Dominik,B?rgel, Frederik,de Vries, Henk,Patberg, Marius,Jan-Smith, Eliot,Frehland, Bastian,Schepmann, Dirk,Heitman, Laura H.,Wünsch, Bernhard
supporting information, p. 409 - 422 (2018/02/14)
The central CB2 receptor represents a promising target for the treatment of neuroinflammatory diseases as CB2 activation mediates anti-inflammatory effects. Recently, the F-18 labeled PET radiotracer [18F]7a was reported,
Formation of aromatic amidoximes with hydroxylamine using microreactor technology
Voeroes, Attila,Baan, Zoltan,Mizsey, Peter,Finta, Zoltan
, p. 1717 - 1726 (2013/01/15)
In this contribution, the application of microreactor technology for amidoxime formation is demonstrated, with different aromatic nitriles reacted with a 50% solution of hydroxylamine (HA) under homogeneous conditions to reach full conversion. All reactio
Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2
DiMauro, Erin F.,Buchanan, John L.,Cheng, Alan,Emkey, Renee,Hitchcock, Stephen A.,Huang, Liyue,Huang, Ming Y.,Janosky, Brett,Lee, Josie H.,Li, Xingwen,Martin, Matthew W.,Tomlinson, Susan A.,White, Ryan D.,Zheng, Xiao Mei,Patel, Vinod F.,Fremeau Jr., Robert T.
scheme or table, p. 4267 - 4274 (2009/04/07)
Structural modifications to the central portion of the N-arylamide oxadiazole scaffold led to the identification of N-arylpiperidine oxadiazoles as conformationally constrained analogs that offered improved stability and comparable potency and selectivity. The simple, modular scaffold allowed for the use of expeditious and divergent synthetic routes, which provided two-directional SAR in parallel. Several potent and selective agonists from this novel ligand class are described.
