886365-46-4

Basic information

• Product Name: 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID;2-Carboxy-5-chloro-3-methylpyridine, 5-Chloro-3-methylpicolinic acid;5-Chloro-3-Methylpicolinic acid
• CAS NO: 886365-46-4
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58104
• Product Categories: Heterocycle-Pyridine series
• Mol File: 886365-46-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 323.878oC at 760 mmHg
• Flash Point: 149.676oC
• Appearance: /
• Density: 1.39g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.04±0.37(Predicted)
• CAS DataBase Reference: 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID(886365-46-4)
• EPA Substance Registry System: 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID(886365-46-4)

Safety Data

• Hazardous Substances Data: 886365-46-4(Hazardous Substances Data)

Usage

Uses

5-Chloro-3-methylpyridine-2-carboxylic acid

InChI:InChI=1/C7H6ClNO2/c1-4-2-5(8)3-9-6(4)7(10)11/h2-3H,1H3,(H,10,11)

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 156072-84-3 5-chloro-3-methylpyridine-2-carbonitrile 
• 65550-77-8 2-bromine-3-methyl-5-chloropyridine 

Downstream Products

• 1624603-92-4 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-methylpyridine-2-carbothioamide 
• 1624603-18-4 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-methyl-2-pyridinecarboxamide 
• 1624604-70-1 N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-methylpicolinamide 
• 1600508-79-9 (R)-N-(3-(8-amino-6-(fluoromethyl)-4,4-dioxido-4-thia-7-azaspiro[2.5]oct-7-en-6-yl)-4-fluorophenyl)-5-chloro-3-methylpicolinamide 
• 1310347-54-6 5-chloro-3-methyl-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide 

Relevant articles and documents

CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula (I), independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and 15 deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimers Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

METHOD OF PREPARING INHIBITORS OF PHOSPHODIESTERASE-4

In one aspect, the present invention is directed to a one pot method of preparing intermediates of Formula V, which are useful in making inhibitors of phosphodiesterase-4: The present invention is also directed to a method of preparing phosphodiesterase inhibitors comprising the Formula