886528-42-3 Usage
Description
4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester is an organoborane compound with the molecular formula C14H17BF3O4. It is characterized by the presence of a pinacol moiety, which is commonly used to protect boronic acids in organic synthesis. 4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester serves as a versatile building block in the synthesis of various pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Synthesis:
4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester is used as a key intermediate in the synthesis of pharmaceuticals for its ability to facilitate the formation of biaryl and biaryl derivatives through Suzuki-Miyaura coupling reactions. These reactions are crucial in creating complex molecular structures that are often found in modern drugs.
Used in Agrochemical Development:
In the agrochemical industry, 4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester is utilized as a reagent in the synthesis of various agrochemicals, contributing to the development of new pesticides and other agricultural products that can improve crop yields and protect plants from diseases.
Used in Medicinal Chemistry Research:
4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester is employed as a research tool in medicinal chemistry to explore new chemical entities and optimize the synthesis of bioactive compounds. Its unique properties allow for the creation of novel drug candidates with potential therapeutic applications.
Used in Material Science and Catalyst Development:
4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester also finds applications in material science, where it can be used to develop new materials with specific properties. Additionally, it plays a role in the development of catalysts that can enhance the efficiency of various chemical reactions, contributing to advancements in green chemistry and sustainable processes.
Check Digit Verification of cas no
The CAS Registry Mumber 886528-42-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,5,2 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 886528-42:
(8*8)+(7*8)+(6*6)+(5*5)+(4*2)+(3*8)+(2*4)+(1*2)=223
223 % 10 = 3
So 886528-42-3 is a valid CAS Registry Number.
886528-42-3Relevant articles and documents
HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE
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, (2021/06/04)
The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I) wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).
Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors
Yang, Yiqing,Cao, Lin,Gao, Hongying,Wu, Yue,Wang, Yaxin,Fang, Fang,Lan, Tianlong,Lou, Zhiyong,Rao, Yu
, p. 4056 - 4073 (2019/05/06)
Viral infections are increasing and probably long-lasting global risks. In this study, a chemical library was exploited by phenotypic screening to discover new antiviral inhibitors. After optimizations from hit to lead, a novel potent small molecule (RYL-634) was identified, showing excellent broad-spectrum inhibition activity against various pathogenic viruses, including hepatitis C virus, dengue virus, Zika virus, chikungunya virus, enterovirus 71, human immunodeficiency virus, respiratory syncytial virus, and others. The mechanism of action and potential targets of RYL-634 were further explored by the combination of activity-based protein profiling and other techniques. Finally, human dihydroorotate dehydrogenase was validated as the major target of RYL-634. We did not observe any mutant resistance under our pressure selections with RYL-634, and it had a strong synergistic effect with some Food and Drug Administration-approved drugs. Hence, there is great potential for developing new broad-spectrum antivirals based on RYL-634.
HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME
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, (2016/12/01)
The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. The compound has a superior TRPA1 antagonist activity, and can provide a medicament useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.
