88675-31-4

Basic information

• Product Name: 2-BROMO-2-PHENYL-1-(γ-FLUOROPHENYL)-ETHANONE
• Synonyms: 2-BroMo-2-phenyl-1-(4-fluorophenyl)-ethanone;Ethanone, 2-broMo-1-(4-fluorophenyl)-2-phenyl-;2-BROMO-2-PHENYL-1-(γ-FLUOROPHENYL)-ETHANONE;2-broMo-1-(4-fluorophenyl)-2-phenylethan-1-one
• CAS NO: 88675-31-4
• Molecular Formula: C₁₄H₁₀BrFO
• Molecular Weight: 293.134
• Mol File: 88675-31-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 356.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.467±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BROMO-2-PHENYL-1-(γ-FLUOROPHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-2-PHENYL-1-(γ-FLUOROPHENYL)-ETHANONE(88675-31-4)
• EPA Substance Registry System: 2-BROMO-2-PHENYL-1-(γ-FLUOROPHENYL)-ETHANONE(88675-31-4)

Safety Data

• Hazardous Substances Data: 88675-31-4(Hazardous Substances Data)

Usage

General Description

"2-BROMO-2-PHENYL-1-(γ-FLUOROPHENYL)-ETHANONE" is a chemical compound that belongs to the family of ketones and contains bromine, phenyl, and fluorophenyl groups. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The presence of the bromine and fluorine atoms makes this compound highly reactive, allowing it to participate in various chemical reactions such as halogenation, nucleophilic substitution, and Grignard reactions. It is important to handle this compound with caution, as it can be harmful if inhaled or ingested and may cause irritation to the skin and eyes.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 82128-66-3 2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetonitrile 
• 103-82-2 phenylacetic acid 
• 347-84-2 1-(4-fluorophenyl)-2-phenylethanone 
• 103-80-0 phenylacetyl chloride 
• 462-06-6 fluorobenzene 

Downstream Products

• 125971-96-2 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide 
• 347-84-2 1-(4-fluorophenyl)-2-phenylethanone 
• 936847-61-9 methyl 4-(2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxopentanamido)benzoate 
• 805241-63-8 tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate 
• 936756-74-0 tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate 
• 719-82-4 2-(4-fluorophenyl)-2-phenylacetonitrile 
• 887355-33-1 4-methyl-3-oxo-N-(2-benzyloxyphenyl)-2-[1-phenyl-2-(4-fluorophenyl)-2-oxoethyl]pentanamide 
• 875771-69-0 4-(4-fluorophenyl)-5-phenyl-2-thiazolehexanoic acid ethyl ester 
• 88675-45-0 2-Azepan-1-yl-1-(4-fluoro-phenyl)-2-phenyl-ethanone 
• 88675-42-7 1-(4-Fluoro-phenyl)-2-phenyl-2-piperidin-1-yl-ethanone 

Relevant articles and documents

METHOD OF PREPARING(3R,5R)-7-(2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-((4-HYDROXYMETHYLPHENYLAMINO)CARBONYL)-PYRROL-1-YL)-3,5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT, AND METHOD OF PREPARING INTERMEDIATES USED THEREIN

The present invention provides a method for preparing (3R,5R)-7-(2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrole-1-yl)-3,5-dihydroxy heptanoic acid hemicalcium salt. The preparation method of the present invention is performed in a convergent synthesis manner in which main structural moieties of a (3R,5R)-7-(2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrole-1-yl)-3,5-dihydroxy heptanoic acid hemicalcium salt are independently synthesized, and then coupled. Accordingly, related substances can be easily controlled and preparing time can be reduced, thus improving the productivity of a compound, and the yield of a final compound can also be increased.

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic activities that are located in two distinct domains. Although the physiological role of the C-terminal hydrolase domain is well-investigated, little is known about its phosphatase activity, located in the N-terminal phosphatase domain of sEH (sEH-P). Herein we report the discovery and optimization of the first inhibitor of human and rat sEH-P that is applicable in vivo. X-ray structure analysis of the sEH phosphatase domain complexed with an inhibitor provides insights in the molecular basis of small-molecule sEH-P inhibition and helps to rationalize the structure-activity relationships. 4-(4-(3,4-Dichlorophenyl)-5-phenyloxazol-2-yl)butanoic acid (22b, SWE101) has an excellent pharmacokinetic and pharmacodynamic profile in rats and enables the investigation of the physiological and pathophysiological role of sEH-P in vivo.

Atorvastatin key intermediate for preparing environmental protection

The present invention provides a kind of atorvastatin key intermediate of environmental protection preparation method, the intermediate body is 4 - fluoro - alpha - [2 - methyl - 1 - oxygen propyl] - gama - oxo - N, beta - diphenyl benzene ding amide, the method uses hydrogen peroxide oxidation of an alkali metal salt of bromide, bromine generated in-situ, brominated 4 '- fluorophenyl - 2 - acetophenone synthesis of 2 - bromo - 1 - (4' - fluoro phenyl) - 2 - acetophenone; above brominated alkali metal salt can be the recovery of the condensation reaction by-product, the obtained 2 - bromo - 1 - (4' - fluoro phenyl) - 2 - acetophenone with isobutyryl acetyl aniline under the action of the acid condensation reaction to obtain the target product, 4 - fluoro - alpha - [2 - methyl - 1 - oxygen propyl] - gama - oxo - N, beta - diphenyl benzene ding amide. When the condensation reaction to form a brominated alkali metal salt recovery, is used for the next batch 4' - fluorophenyl - 2 - acetophenone of the bromination reaction. The method epihalogenohydrine atomic access to fully recycle, greatly reduce the emission of halogen-containing waste. The utilization rate of higher than 80%, saving, full use of resources, reduce environmental pollution, truly environmental protection.