887573-44-6

Basic information

• Product Name: Ethanone, 1-(4,6-dichloro-3-pyridinyl)-
• Synonyms: Ethanone, 1-(4,6-dichloro-3-pyridinyl)-;1-(4,6-Dichloropyridin-3-yl)ethanone;1-(4,6-Dichloropyridin-3-yl)ethan-1-one;5-Acetyl-2,4-dichloropyridine;1-(4,6-dichloro-3-pyridinyl)-Ethanone
• CAS NO: 887573-44-6
• Molecular Formula: C7H5Cl2NO
• Molecular Weight: 190.0267
• Mol File: 887573-44-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 275.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.376±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.28±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(4,6-dichloro-3-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4,6-dichloro-3-pyridinyl)-(887573-44-6)
• EPA Substance Registry System: Ethanone, 1-(4,6-dichloro-3-pyridinyl)-(887573-44-6)

Safety Data

• Hazardous Substances Data: 887573-44-6(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(4,6-dichloro-3-pyridinyl)-, also known as Clorpyrifos Oxon, is a chemical compound featuring a ketone group and a pyridine ring attached to the ethanone backbone. Its IUPAC name is 1-(3,5-dichloro-4-pyridyl)ethan-1-one. This molecule's structure reveals qualities important for its potential biological activity, such as being a pyridine alkaloid. As a part of the organophosphate group of chemicals, it is derived from Clorpyrifos, a pesticide used to kill a variety of insects. It specifically emerges as a metabolite when Clorpyrifos breaks down. Despite its widespread use, the long-term effects of exposure to this compound are not fully understood, although it poses potential health and environmental risks.

Upstream product

• 107836-75-9 4,6-dichloropyridine-3-carbonyl chloride 
• 73027-79-9 4,6-dichloro-nicotinic acid 
• 75-16-1 methylmagnesium bromide 
• 917-54-4 methyllithium 

Downstream Products

• 1092062-74-2 6-chloro-3-methyl-1H-pyrazolo[4,3-c]pyridine 
• 1092063-12-1 6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine 

Relevant articles and documents

SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES

Compounds having the structure of Formula (I) or pharmaceutically acceptable isomers, racemates, hydrates, solvates or salts thereof, where A, R1, R2a, R2b, R2c and R3 are as defined herein, are usefu

PESTICIDAL COMPOUNDS

The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description, (I). The compounds of formula (I), as well as the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof, are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

A series of 2-amino-pyrazolopyridines was designed and synthesized as Polo-like kinase (Plk) inhibitors based on a low micromolar hit. The SAR was developed to provide compounds exhibiting low nanomolar inhibitory activity of Plk1; the phenotype of treated cells is consistent with Plk1 inhibition. A co-crystal structure of one of these compounds with zPlk1 confirms an ATP-competitive binding mode.