88784-91-2

Basic information

• Product Name: (1R,2S)-1-Amino-1-phenylpropan-2-ol hydrochloride
• Synonyms: (1R,2S)-1-Amino-1-phenylpropan-2-ol hydrochloride;(2S,1R)-1-AMINO-1-PHENYLPROPAN-2-OL HCl;(1R,2S)-1-AMINO-1-PHENYLPROPAN-2-OL HCL
• CAS NO: 88784-91-2
• Molecular Formula: C₉H₁₃NO*ClH
• Molecular Weight: 187.66656
• Mol File: 88784-91-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (1R,2S)-1-Amino-1-phenylpropan-2-ol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-1-Amino-1-phenylpropan-2-ol hydrochloride(88784-91-2)
• EPA Substance Registry System: (1R,2S)-1-Amino-1-phenylpropan-2-ol hydrochloride(88784-91-2)

Safety Data

• Hazardous Substances Data: 88784-91-2(Hazardous Substances Data)

Usage

General Description

(1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride is a chemical compound that is a hydrochloride salt of (1R,2S)-1-amino-1-phenylpropan-2-ol, also known as cathinol. It is a chiral compound with two stereocenters, making it optically active. (1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride is a synthetic analog of cathinone, a naturally occurring stimulant found in the khat plant. It has been researched for its potential pharmacological effects, including its activity as a central nervous system stimulant. It may also have potential applications in medicinal chemistry and drug development. As a hydrochloride salt, it is likely to be more stable and water-soluble compared to its freebase form.

Upstream product

• 4518-66-5 (1S,2S)-(-)-1-phenyl-1-propene oxide 
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Downstream Products

• 255060-79-8 (1R,2S)-1-[N-(tert-butoxycarbonyl)amino]-1-phenylpropan-2-ol 
• 526217-23-2 N-[(1R,2S)-2-hydroxy-1-phenylpropyl]octanamide 
• 638211-38-8 (4R,5S)-5-methyl-4-phenyloxazolidin-2-one 
• 255060-80-1 (1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate 
• 255060-81-2 (1R,2R)-1--1-phenylpropan-2-ol 

Relevant articles and documents

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Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositi

3-[3-(piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists

Several 5-HT(ID/1B) receptor agonists are now entering the marketplace as treatments for migraine. This paper describes the development of selective h5-HT(1D)receptor agonists as potential antimigraine agents which may produce fewer side effects. A series of 3-[3-(piperidin-1-yl)propyl]indoles has been synthesized which has led to the identification of 80 (L-772,405), a high- affinity h5-HT(1D) receptor full agonist having 170-fold selectivity for h5- HT(1D) receptors over h5-HT(1B) receptors. L-772,405 also shows very good selectivity over a range of other serotonin and nonserotonin receptors and has excellent bioavailability following subcutaneous administration in rats. It therefore constitutes a valuable tool to delineate the role of h5-HT(1D) receptors in migraine. Molecular modeling and physical properties have been utilized to postulate the binding conformation of these compounds in the receptor cavity.