88790-37-8

Basic information

• Product Name: METHYL (2S)-PYRROLIDIN-2-YLACETATE
• Synonyms: (S)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE;(S)-tert-butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate
• CAS NO: 88790-37-8
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.301
• Mol File: 88790-37-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 190.215 °C at 760 mmHg
• Flash Point: 68.84 °C
• Appearance: /
• Density: 1.006 g/cm³
• Vapor Pressure: 0.548mmHg at 25°C
• Refractive Index: 1.44
• PKA: -2.51±0.40(Predicted)
• CAS DataBase Reference: METHYL (2S)-PYRROLIDIN-2-YLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (2S)-PYRROLIDIN-2-YLACETATE(88790-37-8)
• EPA Substance Registry System: METHYL (2S)-PYRROLIDIN-2-YLACETATE(88790-37-8)

Safety Data

• Hazardous Substances Data: 88790-37-8(Hazardous Substances Data)

Usage

General Description

Methyl (2S)-pyrrolidin-2-ylacetate is a chemical compound with the molecular formula C7H13NO2. It is an ester derivative of the amino acid proline and is commonly used as a flavor and fragrance ingredient. It is known for its fruity and floral odor with a sweet, caramel-like undertone. Methyl (2S)-pyrrolidin-2-ylacetate is often used in the production of perfumes, cosmetics, and food products. It is also used in the pharmaceutical industry for its potential therapeutic properties, including anti-inflammatory and anti-aging effects. METHYL (2S)-PYRROLIDIN-2-YLACETATE is considered safe for use in approved applications and has been deemed generally recognized as safe (GRAS) by the Flavor and Extract Manufacturers Association (FEMA).

InChI:InChI=1/C7H13NO2/c1-10-7(9)5-6-3-2-4-8-6/h6,8H,2-5H2,1H3/t6-/m0/s1

Upstream product

• 186581-53-3 diazomethane 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 56502-01-3 (2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 259868-83-2 (S)-pyrrolidin-2-ylacetic acid methyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 141874-26-2 N-Boc-(S)-proline chloride 
• 84890-94-8 (S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 86971-65-5 pyrrolidin-2-ylidene-acetic acid methyl ester 
• 223118-68-1 tert-butyl (E)-2-(2-methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate 
• 67-56-1 methanol 
• 101130-03-4 tert-butyl (S)-2-(diazoacetyl)pyrrolidine-1-carboxylate 
• 34619-03-9 tert-butyldicarbonate 
• 147-85-3 L-proline 

Downstream Products

• 1338968-17-4 C₂₉H₄₁NO₃ 
• 1178977-16-6 (S)-1,1-bis(4-propylphenyl)-2-(pyrrolidin-2-yl)ethanol 
• 1338968-19-6 C₃₃H₄₉NO₃ 
• 1178977-17-7 (S)-1,1-bis(4-pentylphenyl)-2-(pyrrolidin-2-yl)ethanol 
• 1338968-20-9 C₂₇H₂₅F₁₂NO₃ 
• 1178977-14-4 (S)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)-2-(pyrrolidin-2-yl)ethanol 
• 1178977-11-1 (S)-1,1-diphenyl-2-(pyrrolidin-2-yl)ethanol 
• 1338968-21-0 C₁₉H₂₁NO₂ 
• 1338968-22-1 C₂₁H₂₅NO₂ 
• 1338968-24-3 C₂₅H₃₃NO₃ 
• 1338968-04-9 C₂₃H₃₁NO 
• 1178977-28-0 C₂₀H₂₅NO 
• 1338968-12-9 C₂₃H₂₉NO₃ 
• 1338968-14-1 C₂₅H₃₃NO₃ 

Relevant articles and documents

Tetrahydropyrido [3, 4-d] pyrimidine derivative and medical application thereof

The invention relates to a compound as shown in a general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or eutectic crystal thereof, an intermediate and a preparation method thereof, and application of the compound in preparation of drugs for treating diseases related to KRas-G12C activity or expression quantity.

A systematic study of chiral homoprolinols and their derivatives in the catalysis of enantioselective addition of diethylzinc to aldehydes

Homoprolinol analogs, a class of optically active γ-amino alcohols, were examined systematically in the enantioselective addition reactions of diethylzinc to aldehydes. By comparison of the results catalyzed by these γ-amino alcohols with those by the β-amino alcohols based on pyrrolidine architecture reported in the literature references, we have observed that the γ-amino alcohols are superior to the corresponding β-amino alcohols when the nitrogen and the oxygen are unsubstituted. Among the homoprolinols we tested, 2b gave the best results (45-88% yields, 44-81% ee) in the addition reactions. To the best of our knowledge, 2b has been noticed as one of the most efficient γ-amino alcohol catalysts based on pyrrolidine framework.

Asymmetric synthesis of homoproline derivatives via Rh(I)-catalyzed hydrogenation using chiral bisphosphines as ligands

It has been demonstrated for the first time that Rh(I)-catalyzed asymmetric hydrogenation of cyclic β-enamino acid derivatives 1 using chiral bisphosphines could be a highly efficient synthetic method for optically active homoproline derivatives. The enantioselectivity and conversion yield were largely dependent upon the chiral ligand. Using the Me-BDPMI forming a seven-membered metal chelate, the N-acetylated β-enamino acid methyl ester 1a was hydrogenated to give optically active homoproline derivative 2a with 100% conversion and 96% ee.