888951-64-2

Basic information

• Product Name: 5-fluoro-1-(2-fluorophenyl)-3-(3-piperidylmethoxy)indazole
• CAS NO: 888951-64-2
• Molecular Formula: C₁₉H₁₉F₂N₃O
• Molecular Weight: 343.37
• Mol File: 888951-64-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 429.5°C at 760 mmHg
• Flash Point: 213.5°C
• Density: 1.33g/cm³
• Vapor Pressure: 1.4E-07mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 5-fluoro-1-(2-fluorophenyl)-3-(3-piperidylmethoxy)indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-1-(2-fluorophenyl)-3-(3-piperidylmethoxy)indazole(888951-64-2)
• EPA Substance Registry System: 5-fluoro-1-(2-fluorophenyl)-3-(3-piperidylmethoxy)indazole(888951-64-2)

Safety Data

• Hazardous Substances Data: 888951-64-2(Hazardous Substances Data)

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 1050211-07-8 (S)-3-[5-fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 364356-44-5 (S)-<<(methylsulfonyl)oxy>methyl>piperidine-1-carboxylic acid tert-butyl ester 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 888952-52-1 5-fluoro-1-(2-fluorophenyl)-1H-indazol-3-ol 
• 2368-80-1 2-fluorophenylhydrazine 
• 888952-51-0 2-amino-5-fluoro-N'-(2-fluorophenyl)benzohydrazide 
• 4606-65-9 3-(hydroxymethy)piperidine 
• 2924-15-4 (2-fluorophenyl)hydrazine hydrochloride 
• 321-69-7 5-fluoroisatoic anhydride 

Relevant articles and documents

The synthesis of (S)-5-fluoro-1-(2-fluorophenyl)-3-(piperidin-3-ylmethoxy)- 1H-indazole, a norepinephrine/serotonin reuptake inhibitor for the treatment of fibromyalgia

Compound 1, a norepinephrine/serotonin reuptake inhibitor (NSRI) for the treatment of fibromyalgia, has been synthesized in optically pure form in six linear steps and 48% overall yield with no chromatography. This route features a novel and efficient intramolecular cyclization to generate the indazolone core via a diazotization reaction and the preparation of a stable polymorph of the tartaric acid salt as the desired final form. The original synthetic route has been modified to avoid the use of toxic and expensive reagents, thus enabling the preparation of multigram quantities of API for toxicology studies.